Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
140 participants
OBSERVATIONAL
2027-07-01
2028-12-31
Brief Summary
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* To optimize and evaluate multiple kidney MRI methods; and
* To investigate the potential of MRI in the assessment of transplant kidney functions; To achieve these goals, we will perform pilot MRI studies with kidney transplant patients. We will study if MRI can reflect different levels of kidney function. The investigators will also evaluate if MRI can differentiate causes for declining kidney function. Finally, the investigators will explore how MRI measures changes before and after medical treatment for worsening kidney function.
You may be invited for MRI exams with different exam options. An MRI exam may use either of two types of MRI machines at the center for magnetic resonance research (CMRR): the 3 Tesla (3T) scanner and the 7 Tesla (7T) scanner. You may also be invited for a multi-session exam. A description of the MRI exam types with different exam options and the types of multi-session exams is provided later in this document.
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Detailed Description
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Subjects may be invited for MRI exams with different exam options. An MRI exam may use either of two types of MRI machines at the CMRR: the 3T scanner and the 7T scanner. Subjects may also be invited for a multi-session exam. A description of the MRI exam types with different exam options and the types of multi-session exams is provided later in this document.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Patients with Stable Renal Function
Patients will be given MRI
Magnetic Resonance Imaging
Investigate anatomic and functional characteristics of transplant kidneys using MRI
Patients with Worsening Renal Function due to complications
MRI
Magnetic Resonance Imaging
Investigate anatomic and functional characteristics of transplant kidneys using MRI
Interventions
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Magnetic Resonance Imaging
Investigate anatomic and functional characteristics of transplant kidneys using MRI
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Capable to consent
* English speaking
* For studies with patients with fast worsening renal function: An abrupt (within 48 h) reduction in kidney function currently defined as a percentage increase in serum creatinine of ≥50% (1.5-fold from baseline), or a reduction in urine output (documented oliguria of less than 0.5 mL/kg/h for more than 6 h).
* For patients with recovered renal allograft function after therapy: renal allograft function as measured by glomerular filtration rate (eGRF) has been recovered and stabilized above a clinical acceptable level, such as 15 ml/min/1.73 mm2.
Exclusion Criteria
* Acute and chronic pulmonary disease
* Pregnancy as reported in CMRR Safety Screen
* Ferromagnetic implants
* Any foreign metal objects in the body
* History of shrapnel or shot gun injury
* Cardiac pacemakers
* Defibrillator
* Neuronal stimulator
* Magnetic aneurysm clip
* Large tattoos on the abdomen or the brain and neck, as determined by CMRR Safety Officer
* Hip replacement
* Too large to fit in the magnet (BMI \>= 40, approx.)
* Severe claustrophobia
18 Years
75 Years
ALL
No
Sponsors
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University of Minnesota
OTHER
Responsible Party
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Locations
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CMMR
Minneapolis, Minnesota, United States
Countries
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Other Identifiers
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1610M96261
Identifier Type: -
Identifier Source: org_study_id
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