Efficacy and Safety of Aluminaid Versus Hydrogel Wound Dressings

NCT ID: NCT03190655

Last Updated: 2018-03-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

6 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-03-01

Study Completion Date

2018-03-05

Brief Summary

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Burn injury is the result of an energy transfer that destroys the skin and adjacent tissues. Partial thickness burn wounds are painful and difficult to manage. The aim of burn treatment in partial thickness burns is to promote rapid wound healing, decrease pain, protect wound from infections, minimize scar formation and functional impairment In recent years, there are progressive development of new dressing material with a variety of option for depth adapted wound management. Many wound dressings are available for superficial and partial thickness burns. Hydrogel based wound dressing provides good biocompatibility with the skin and mucosa and promotes hydration of the wound bed.

Aluminaid wound dressings is a hydrogel based wound dressing that is integrated with aluminium that was designed to reduce acute pain in the treatment of superficial and partical thickness burn injuries.

Up to date, no evidence regarding integrated with aluminium sheet in hydrogel based wound dressings for the use in partial thickness burns. Therefore this trials is aimed to evaluate the efficacy and safety of Aluminaid versus Hydrogel for the treatment of partial thickness burns.

Detailed Description

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This is a prospective, randomized, open label, active controlled trial that aim to evaluate the efficacy and safety of Aluminaid versus Hydrogel wound dressings in the treatment of partial thickness burns.

The study is a multi center trial in children and adults of 12 - 65 years old with partial thickness burns.

Conditions

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Partial-thickness Burn

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Patients who attend the clinical sites, presenting with untreated partial thickness burns less than 4 hours, and meet the inclusion and exclusion criteria
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Caregivers Outcome Assessors
The person that assess the degree of epithelization will be presented with photos of the burn conditions and will not be given information of the patient's treatment.

Study Groups

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Aluminaid

Treatment group: Aluminaid wound dressing

Group Type EXPERIMENTAL

Aluminaid

Intervention Type DEVICE

Aluminaid wound dressings is a hydrogel based wound dressing that is integrated with aluminium

Hydrogel

Hydrogel wound dressing (Trademark: Burnshield)

Group Type ACTIVE_COMPARATOR

Hydrogel

Intervention Type DEVICE

Hydrogel based wound dressing

Interventions

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Aluminaid

Aluminaid wound dressings is a hydrogel based wound dressing that is integrated with aluminium

Intervention Type DEVICE

Hydrogel

Hydrogel based wound dressing

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Adults and children of 12 - 65 years old
* Partial thickness thermal burns of minimally 1% total body surface area (TBSA)
* Admission of less than 4 hours of burn injury
* Patients/legal guardian still have the ability to undergo examinations and give written informed consent.

Exclusion Criteria

* Total body surface area (TBSA) of more than 20%
* Burns caused by chemicals, electricity or radiation
* Superficial and partial thickness burns located on the faces, palms, soles, genitalia, perineum and joint areas
* Superficial and partial thickness burns with compartment syndrome
* Superficial and partial thickness burns with a history of life-threatening trauma
* Had concomitant disease such as diabetes mellitus
* Signs of infected burns
* Patients with known allergies to product containing aluminium, hydrogel or a history of contact dermatitis
* Other conditions which according to the investigator's judgment are not appropriate to be included in the study.
* Treated with other agents before attend to clinic (oil, tooth paste, betadine, rivanol etc)
Minimum Eligible Age

12 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Melva Louisa

OTHER

Sponsor Role lead

Responsible Party

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Melva Louisa

Trial Director

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Wawaimuli Arozal, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Indonesia University

Locations

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Clinic of Clinical Research Supporting Unit

Jakarta Pusat, Jakarta Special Capital Region, Indonesia

Site Status

Countries

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Indonesia

References

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Grippaudo FR, Carini L, Baldini R. Procutase versus 1% silver sulphadiazine in the treatment of minor burns. Burns. 2010 Sep;36(6):871-5. doi: 10.1016/j.burns.2009.10.021. Epub 2010 Jan 15.

Reference Type BACKGROUND
PMID: 20079572 (View on PubMed)

Cancio LC, Lundy JB, Sheridan RL. Evolving changes in the management of burns and environmental injuries. Surg Clin North Am. 2012 Aug;92(4):959-86, ix. doi: 10.1016/j.suc.2012.06.002.

Reference Type BACKGROUND
PMID: 22850157 (View on PubMed)

Hettiaratchy S, Dziewulski P. ABC of burns: pathophysiology and types of burns. BMJ. 2004 Jun 12;328(7453):1427-9. doi: 10.1136/bmj.328.7453.1427. No abstract available.

Reference Type BACKGROUND
PMID: 15191982 (View on PubMed)

Lars PK, Giretzlehner M, Trop M, Parvizi D, Spendel S, Schintler M, Justich I, Wiedner M, Laback C, Lumenta DB. The properties of the "ideal" donor site dressing: results of a worldwide online survey. Ann Burns Fire Disasters. 2013 Sep 30;26(3):136-41.

Reference Type BACKGROUND
PMID: 24563639 (View on PubMed)

Rowan MP, Cancio LC, Elster EA, Burmeister DM, Rose LF, Natesan S, Chan RK, Christy RJ, Chung KK. Burn wound healing and treatment: review and advancements. Crit Care. 2015 Jun 12;19:243. doi: 10.1186/s13054-015-0961-2.

Reference Type BACKGROUND
PMID: 26067660 (View on PubMed)

Selig HF, Lumenta DB, Giretzlehner M, Jeschke MG, Upton D, Kamolz LP. The properties of an "ideal" burn wound dressing--what do we need in daily clinical practice? Results of a worldwide online survey among burn care specialists. Burns. 2012 Nov;38(7):960-6. doi: 10.1016/j.burns.2012.04.007. Epub 2012 May 8.

Reference Type BACKGROUND
PMID: 22571855 (View on PubMed)

Serrano C, Boloix-Tortosa R, Gomez-Cia T, Acha B. Features identification for automatic burn classification. Burns. 2015 Dec;41(8):1883-1890. doi: 10.1016/j.burns.2015.05.011. Epub 2015 Jul 15.

Reference Type BACKGROUND
PMID: 26188898 (View on PubMed)

Wasiak J, Cleland H, Campbell F, Spinks A. Dressings for superficial and partial thickness burns. Cochrane Database Syst Rev. 2013 Mar 28;2013(3):CD002106. doi: 10.1002/14651858.CD002106.pub4.

Reference Type BACKGROUND
PMID: 23543513 (View on PubMed)

Other Identifiers

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Aluminaid

Identifier Type: -

Identifier Source: org_study_id

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