Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients With Chronic Periodontitis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-12-25

Study Completion Date

2015-06-16

Brief Summary

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This case control-study measures the levels of Interleukin-17 in gingival crevicular fluid and placental tissue samples of pregnant females as a possible marker in determining whether or not an association exists between chronic periodontitis and preterm labor. Interleukin-17 is a pro-inflammatory cytokine whose levels have been proven to increase in periodontal disease.

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Detailed Description

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Conditions

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Chronic Periodontitis Preterm Labor

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Preterm/Chronic Periodontitis

Included ten female patients who underwent spontaneous preterm birth and were diagnosed with chronic periodontitis upon clinical examination

No interventions assigned to this group

Preterm/Healthy Periodontium

Included ten female patients who underwent spontaneous preterm birth and who had a healthy periodontium upon clinical examination

No interventions assigned to this group

Term/Chronic Periodontitis

Included ten female patients who underwent spontaneous normal term birth and were diagnosed with chronic periodontitis upon clinical examination

No interventions assigned to this group

Term/Healthy Periodontium

Included ten female patients who underwent spontaneous normal term birth and who had a healthy periodontium upon clinical examination (Armitage1999)

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. Within the age range of 18-35 years
2. Free of any systemic diseases as referenced from Burket's Oral Medicine health history questionnaire (Glick2008)
3. Spontaneous normal term birth at ≥37 weeks of gestation without any obstetrical or medical complications
4. Spontaneous preterm birth (PTB) at \<37 weeks of gestation after uterine contraction or rupture of membranes (Keelan1999)

Exclusion Criteria

1. History of medications that may affect the study outcome, such as: current use of systemic corticosteroids or antibiotics for at least one month
2. Genital and urinary tract infections
3. Existing hypertension and diabetes mellitus before pregnancy, autoimmune disease, asthma, and chronic renal disease
4. Multiple pregnancies, cervical cerculage, abnormal placentation, past history of preterm delivery, or antepartum hemorrhage
5. Low or high maternal body mass index

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes