An Egg Based Breakfast Maintains Flexibility in Older Adults

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

33 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-12-14

Study Completion Date

2013-10-30

Brief Summary

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Aging is associated with an increased risk for metabolic diseases, such as type 2 diabetes and cardiovascular disease. There is reason to believe that the time of day when specific food groups are eaten affects this risk. The investigators propose that eating foods made up of fat and protein (such as eggs) in the morning for breakfast, rather than foods made up of carbohydrates (such as white-bread toast or sugary cereal) may promote a healthier metabolism. This is because the body is designed to burn fat during times of fasting, such as overnight, during sleep. Thus, the body is not prepared to burn sugar early in the morning, when most people eat breakfast. Studies with mice have shown that a sugary breakfast meal inhibits the ability of the body to burn fat for the entire day. In contrast, a breakfast meal with more fat enabled the animals to burn fat as well as other fuels throughout the day. The ability to burn fat is thought to minimize risk for obesity, as well as related diseases such as type 2 diabetes and heart disease. The purpose of this study is to determine if, in older adult humans, consumption of a lower-carbohydrate breakfast meal (relative to a higher-carbohydrate meal) is associated with a healthier metabolism.

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Detailed Description

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Conditions

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Diabetes Heart Diseases

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Patients were randomized to either a egg breakfast or a carbohydrate breakfast

Study Groups

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High fat breakfast

45% fat 35% Carbohydrate 20% protein

Group Type EXPERIMENTAL

High fat breakfast

Intervention Type OTHER

High fat breakfast

Higher carbohydrate breakfast

60% carbohydrate 20% fat 20% protein

Group Type EXPERIMENTAL

Higher carbohydrate breakfast

Intervention Type OTHER

Higher carbohydrate breakfast

Interventions

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High fat breakfast

Intervention Type OTHER

Higher carbohydrate breakfast

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* • Age 55-75

* Body mass index 24-29 kg/m2

Exclusion Criteria

* • Current practice of greater than 2h/wk of moderate intentional exercise

* Uncontrolled diabetes
* Unwillingness to eat study diets
* Use of any medication known to affect metabolism
* History of eating disorder
* Difficulty chewing and swallowing solid food
* Digestive diseases
* Cognitive impairment
* Depression
* Recent weight change (+/- 10 lbs. in the last 12 mo.)
* Poorly controlled blood pressure (SBP \> 159 or DBP \>95 mm Hg)
* History of non-skin cancer in the last 5 y
* Cardiovascular disease event in the past 6 mo.
* Severe pulmonary disease
* Renal failure
* Major liver dysfunction (elevation of liver transaminases \>3x normal in past 2 y; current/recent smoker (within 6 mo.)
* Use of estrogen or testosterone replacement therapy
* Current use of oral corticosteroids \>5 days/month on average
* Current use of medications for treatment of psychosis or manic-depressive illness
* Use of weight loss medications in the previous 3 months
* Unable to adhere to diet recommendations

Minimum Eligible Age

55 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes