Evaluation of Egg Consumption and Its Enrichment With Annatto on Cardiovascular Risk and Satiety in Healthy Adults

NCT ID: NCT05088577

Last Updated: 2021-10-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

105 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-10-11

Study Completion Date

2020-12-18

Brief Summary

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Healthy adult volunteers (n= 105; 18-59 years) were randomly allocated to consume daily for 8 weeks, either two whole eggs (egg group), two whole eggs added with annatto (annatto-enriched egg group), or two egg whites (control). Volunteers were asked to continue with the habitual physical activity and diet, except for the consumption of additional eggs, egg whites or annatto.

It is hypothesized that participants consuming eggs would have a less atherogenic lipid profile, feel more satisfied and increase antioxidant levels in blood, compared to the control group. Participants in the annatto-enriched egg group would have greater antioxidant capacity than the egg group and compared to control.

Detailed Description

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Conditions

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Healthy Volunteers

Keywords

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Egg Bixa orellana Annatto cardiovascular risk factors clinical trial

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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Whole egg

Two whole eggs (50g each) to be eaten daily during 8 weeks

Group Type EXPERIMENTAL

Whole egg

Intervention Type DIETARY_SUPPLEMENT

Daily consumption of two whole eggs during 8 weeks

Annatto-enriched egg

Two whole eggs (50g each) enriched with annatto (Bixa orellana L.) to be eaten daily during 8 weeks. Dose of annatto: 1,2 mg bixin/kg of body weight.

Group Type EXPERIMENTAL

Annatto-enriched egg

Intervention Type DIETARY_SUPPLEMENT

Daily consumption of two whole eggs enriched with annatto during 8 weeks

Egg whites - Control

Two egg whites to be eaten daily during 8 weeks

Group Type PLACEBO_COMPARATOR

Egg whites - Control

Intervention Type DIETARY_SUPPLEMENT

Daily consumption of two eggs whites during 8 weeks

Interventions

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Whole egg

Daily consumption of two whole eggs during 8 weeks

Intervention Type DIETARY_SUPPLEMENT

Annatto-enriched egg

Daily consumption of two whole eggs enriched with annatto during 8 weeks

Intervention Type DIETARY_SUPPLEMENT

Egg whites - Control

Daily consumption of two eggs whites during 8 weeks

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Age: 18-59 years
* Body Mass Index (BMI): 18,5 - 29,9 kg/m2
* Healthy volunteers
* Good disposition to consume either eggs, egg whites or eggs added with annatto
* To have signed the informed consent

Exclusion Criteria

* Fasting blood triglycerides \> 500mg/dL, Total Cholesterol \> 240mg/dL, glucose \> 126mg/dL or diabetes.
* Blood pressure: \>140/90 mmHg.
* History or having any of the following: liver, kidney, or heart disease, cancer, endocrine or gastrointestinal disorders -especially those that limit food absorption.
* Use of medications to lower blood lipids or glucose.
* Consumption of multivitamins or nutraceuticals.
* Plan to lose body weight, pregnancy or breastfeeding.
* Any known allergy or intolerance to eggs or annatto.
Minimum Eligible Age

18 Years

Maximum Eligible Age

59 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnología (COLCIENCIAS)

OTHER_GOV

Sponsor Role collaborator

Universidad de Antioquia

OTHER

Sponsor Role lead

Responsible Party

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Jacqueline Barona Acevedo

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jacqueline Barona-Acevedo, PhD

Role: PRINCIPAL_INVESTIGATOR

Universidad de Antioquia

Locations

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Sede de Investigación Universitaria - Universidad de Antioquia

Medellín, Antioquia, Colombia

Site Status

Countries

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Colombia

Other Identifiers

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111580763245

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

754-2018

Identifier Type: -

Identifier Source: org_study_id