Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
596 participants
OBSERVATIONAL
2017-06-01
2020-12-31
Brief Summary
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Detailed Description
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evaluate the correlation between mRs score and the baseline characteristics Functional outcomes will be evaluated using the modified Rankin score (mRS) score, which is one of the most frequently used scores in acute neurological diseases \[18\]. A poor outcome will be defined by a mRS score \> 2 (functional dependence or death). The investigator usually evaluates this score if the patient is still in the hospital 90 days after admission. Patients discharged from hospital within 90 days following ICU admission without major disability (mRS 0, 1 or 2) are considered to have a good outcome. Patients discharged within 90 days with a disability will be classified for the study according to the latest available data. Patients will not be contacted directly by the investigator for the study purposes.
Secondary objectives :
To identify additional prognosis factors : the clinical, radiological, biological and neurophysiological factors associated with poor outcome for patients admitted to the ICU with AE
* Day 28 mortality, in-ICU mortality, in-hospital mortality
* Major systemic complications (septic shock, hyponatremia, nosocomial pneumonia, catheter-related BSI, overt gastroenteral bleeding, pulmonary embolism)
* Major intracranial complications during ICU stay
* Status epilepticus
* Brain death
* Empyema/cerebral abscess
* Cerebral ischemia
* Intracranial bleeding
* ICP monitoring
* Neurosurgery
The cause of death will be categorized into 2 categories:
* Systemic causes (cardiovascular failure, MOF)
* Neurological cause (Diffuse neurologic injury or withdrawal of care)
Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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None, non-interventional study
Not applicable, non-interventional study
Eligibility Criteria
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Inclusion Criteria
* non-opposition to participate in the study (or consent if applicable according to local legislation)
* Impaired consciousness (altered mentation, stupor, or personality changes) for a duration ≥ 24 h, without obvious explanation
* A score on the Glasgow Coma Scale \< or =13 at ICU admission
* A Cerebrospinal fluid pleocytosis \> = 5 cell / mm3
* At least 2 of the following :
* Fever (≥ 38.0 °C) within 72 hours before or after admission
* Generalized or partial seizures non-attributable to pre-existing epilepsy
* New onset focal neurological deficit
* Parenchymal abnormalities on MRI compatible with AE
* EEG alterations compatible with AE.
Exclusion Criteria
* febrile encephalopathy associated with another diagnosis (sepsis, neurological disease with aspiration pneumonia ... )
18 Years
ALL
No
Sponsors
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ICUREsearch
INDUSTRY
Responsible Party
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Principal Investigators
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Jean François Timsit
Role: STUDY_CHAIR
ICUREsearch
Romain Sonneville
Role: PRINCIPAL_INVESTIGATOR
Hôpital Bichat, APHP
Locations
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Medical University of Innsbruck
Innsbruck, , Austria
Centre Hospitalier d'Angoulême
Angoulême, , France
Centre Hospitalier Annecy Genevois
Annecy, , France
Hôpital Victor Dupouy
Argenteuil, , France
Hôpital Ambroise Paré
Boulogne-Billancourt, , France
CHU Brest
Brest, , France
Hôpital Pierre Wertheimer
Bron, , France
Centre Hospitalier René Dubos
Cergy-Pontoise, , France
CH de Charlesville-Mézières
Charleville-Mézières, , France
Les Hôpitaux de Chartres
Chartres, , France
Centre Hospitalier Châlons en Champagne
Châlons-en-Champagne, , France
Centre Hospitalier Public du Cotentin
Cherbourg, , France
Hôpital Antoine Béclère
Clamart, , France
CHU Gabriel Montpied
Clermont-Ferrand, , France
APHP Colombes - Louis Mourier
Colombes, , France
Centre Hospitalier du Sud Francilien
Corbeil-Essonnes, , France
Hôpitaux Universitaires Henri Mondor
Créteil, , France
Centre hopsitalier de Dieppe
Dieppe, , France
Centre hospitalier Sud Essone
Étampes, , France
CHU Grenoble
Grenoble, , France
Marne la Vallée - Meaux
Jossigny, , France
CH Vendée
La Roche, , France
CH du Mans
Le Mans, , France
Hôpital R Salengro
Lille, , France
Centre Hospitalier Lorient
Lorient, , France
Hôpital Edouard Herriot
Lyon, , France
Institut Paoli-Calmettes
Marseille, , France
Hôpital de la Timone
Marseille, , France
CHU Hôpital Nord
Marseille, , France
CHR Metz-Thionville
Metz, , France
CHU Lapeyronie
Montpellier, , France
CHU de Nantes
Nantes, , France
Hôpital de la Source
Orléans, , France
Hôpital Saint Louis
Paris, , France
Hôpital Cochin
Paris, , France
Hôpital Européen Georges-Pompidou
Paris, , France
Hôpital Bichat Claude Bernard
Paris, , France
Hôpitaux universitaires Est Parisien, Tenon
Paris, , France
Groupe Hospitalier Paris Saint-Joseph
Paris, , France
Groupe hospitalier Pitié-Salpêtrière
Paris, , France
Fondation Opthalmologique Adolphe de Rothschild
Paris, , France
Centre Hospitalier de Pau
Pau, , France
Centre Hospitalier Intercommunal de Poissy
Poissy, , France
CHU Rennes
Rennes, , France
CH Roanne
Roanne, , France
Centre hospitalier de Saint-Denis, Hôpital DELAFONTAINE
Saint-Denis, , France
CHU de Toulouse Purpan
Toulouse, , France
Centre hospitalier de Tourcoing
Tourcoing, , France
Hôpital André Mignot
Versailles, , France
CH des 2 vallées, Site Longjumeau
Longjumeau, Île-de-France Region, France
Ims & Sum Hospital
Bhubaneswar, , India
Sanjay Gandhi Post Graduate Institute of Medical Sciences
Lucknow, , India
Institute Of Medical Sciences Banaras Hindu University
Lucknow, , India
King George's medical university
Lucknow, , India
Sri Ramachandra Institute of Higher Education and Research
Lucknow, , India
Azienda USL Toscana Centro
Florence, , Italy
San Gerardo Hospital
Monza, , Italy
Università Cattolica del Sacro Cuore
Roma, , Italy
Academic Medical Center
Amsterdam, , Netherlands
Hospital Vall d'Hebron
Barcelona, , Spain
Hospital de la Santa Creu
Barcelona, , Spain
Germans Trias i Pujol
Barcelona, , Spain
Hospital Universitario Puerta de Hierro Majadahonda
Madrid, , Spain
Complexo Hospitalario Universitario de Ourense
Ourense, , Spain
Hospital Universitari Arnau de Vilanova
Zaragoza, , Spain
Countries
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References
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Sonneville R, de Montmollin E, Contou D, Ferrer R, Gurjar M, Klouche K, Sarton B, Demeret S, Bailly P, da Silva D, Escudier E, Le Guennec L, Chabanne R, Argaud L, Ben Hadj Salem O, Thyrault M, Frerou A, Louis G, De Pascale G, Horn J, Helbok R, Geri G, Bruneel F, Martin-Loeches I, Taccone FS, De Waele JJ, Ruckly S, Staiquly Q, Citerio G, Timsit JF; EURECA Investigator Study Group. Clinical features, etiologies, and outcomes in adult patients with meningoencephalitis requiring intensive care (EURECA): an international prospective multicenter cohort study. Intensive Care Med. 2023 May;49(5):517-529. doi: 10.1007/s00134-023-07032-9. Epub 2023 Apr 6.
Other Identifiers
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0008
Identifier Type: -
Identifier Source: org_study_id
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