Neurological Blood-based Biomarkers and Cognitive Disorders in Critically Ill Survivors.

NCT ID: NCT05953311

Last Updated: 2023-07-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-06-23

Study Completion Date

2025-12-31

Brief Summary

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Cognitive disorders are common after intensive care. Currently, their diagnosis is based on clinical tests. The investigators plan to study the relationship between different neurological blood biomarkers (cytokines, S100β protein, neuron specific enolase, total Tau protein and neurofilament light chain) and the occurrence of cognitive disorders during the three months following intensive care discharge.

Detailed Description

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Conditions

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Intensive Care Unit Syndrome Post-intensive Care Syndrome Cognitive Disorder

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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ICU survivors

Cohort of patients who survive an ICU stay of at least 7 days

Blood analysis

Intervention Type OTHER

Blood analysis for neurological biomarkers measurements

Cognitive tests

Intervention Type OTHER

Questionnaires assessing cognitive function

Interventions

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Blood analysis

Blood analysis for neurological biomarkers measurements

Intervention Type OTHER

Cognitive tests

Questionnaires assessing cognitive function

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Anticipated ICU stay of at least 7 days for sepsis, acute respiratory distress syndrome, severe burns
* French speaking

Exclusion Criteria

* hearing loss or blindness
* mental retardation
* known cognitive disorders or dementia
* ICU admission for neurological disease
* refusal
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Liege

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Anne-Françoise Rousseau, MD, PhD

Role: STUDY_DIRECTOR

University hospital of Liège

Locations

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University Hospital of Liège

Liège, , Belgium

Site Status RECRUITING

Countries

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Belgium

Central Contacts

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Anne-Françoise Rousseau, MD, PhD

Role: CONTACT

+3243234776

Facility Contacts

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Anne-Françoise Rousseau, MD, PhD

Role: primary

+3243234776

Other Identifiers

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COGNISI

Identifier Type: -

Identifier Source: org_study_id

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