New Proteins in Body Fluids as Potential Biomarker for Alzheimer's Disease: a Pilot Study

NCT ID: NCT01773915

Last Updated: 2014-01-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-12-31

Study Completion Date

2014-06-30

Brief Summary

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Alzheimer's disease (AD) is the most common neurodegenerative disorder afflicting the elderly. Currently, some biochemical tests performed on Cerebrospinal Fluid (CSF) samples have demonstrated to discriminate to some extend between AD and non-AD individuals based on the levels of tau, phospho-tau or Aβ42. We aim to investigate newly identified proteins whose levels increase during the Braak Stages of AD that are accessible in other body fluids such as blood, urine or saliva. The detection of these proteins would allow performing simple tests in case its levels were confirmed to be associated with the AD pathology.

Detailed Description

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We do not desire to provide a more extensive description

Conditions

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Alzheimer Disease, Late Onset

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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AD patients

Subject fulfilling the McKhann criteria for clinical probable AD

No interventions assigned to this group

Healthy elder persons

Healthy controls with abscence of any cognitive disorder

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

\- mild to moderate AD

Exclusion Criteria

\-
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Universitaire Ziekenhuizen KU Leuven

OTHER

Sponsor Role lead

Responsible Party

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Prof Dr Jos Tournoy

MD PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Bart De Strooper

Role: PRINCIPAL_INVESTIGATOR

KU Leuven

Francesc Guix

Role: PRINCIPAL_INVESTIGATOR

KU Leuven

Locations

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UZ Leuven

Leuven, , Belgium

Site Status RECRUITING

Countries

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Belgium

Central Contacts

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Jos Tournoy

Role: CONTACT

+3216342640

Facility Contacts

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Jos Tournoy

Role: primary

References

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Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA. Large-scale proteomics and phosphoproteomics of urinary exosomes. J Am Soc Nephrol. 2009 Feb;20(2):363-79. doi: 10.1681/ASN.2008040406. Epub 2008 Dec 3.

Reference Type BACKGROUND
PMID: 19056867 (View on PubMed)

Other Identifiers

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s54591

Identifier Type: -

Identifier Source: org_study_id

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