Distal Tibia Sarcoma Treatment Using Allograft Arthrodesis of the Ankle

NCT ID: NCT03129672

Last Updated: 2019-02-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-05-20

Study Completion Date

2019-08-31

Brief Summary

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The study show the clinical results of limb salvage for primary malignant bone tumor of the distal tibia using block excision of the tumor and reconstruction with allograft arthrodesis with different methods of fixation (plates or intramedullary nail system)

Detailed Description

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It is well known that before the 1980's the usual treatment for the sarcomas of the distal tibia was amputation (1). Currently, however, after the improvement of the chemotherapy treatments, potential reconstructions of the area in well studied patients are possible, and for that we have a wide range: auto graft, allograft and prosthetic reconstructions (2, 3)

Is important to know that osteosarcoma still meant the principal diagnosis, followed by the Ewing sarcoma and synovial sarcoma, but their malignant potency is lower than when they are present in the rest of the body (4, 5, and 6)

The purpose of this study is to recollect the patients' data followed from different institutions and countries that have the criteria for their inclusion in the study (primary malignant bone tumor of the distal tibia that underwent block excision of the tumor and reconstruction with allograft arthrodesis from the patient management for any of the multidisciplinary sarcoma team including in this study).

Conditions

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Bone Neoplasm

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Interventions

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allograft arthrodesis of ankle

patients that underwent trought a block resection of a malignant tumor of the distal tibia and reconstruction with allograft arthrodesis

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

\- all patients with histopathologyc diagnosis of a primary malignant bone tumor at the distal tibia that went through a tumor resection and received reconstruction with allograft as first surgical treatment

Exclusion Criteria

* none histopatologic proved diagnosis
* patients that received other kind of surgical treatment
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospital del Niño "Dr. José Renán Esquivel"

OTHER

Sponsor Role collaborator

Patricia Bonilla

OTHER

Sponsor Role lead

Responsible Party

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Patricia Bonilla

Orthopedic Oncologist MD

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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patricia bonilla, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital del Niño

Locations

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Panama Children Hospital

Panama City, , Panama

Site Status RECRUITING

Countries

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Panama

Central Contacts

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patricia bonilla, MD

Role: CONTACT

Jorge Navia, MD

Role: CONTACT

Facility Contacts

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patricia bonilla, MD

Role: primary

+507-5129813 ext. 150

Jorge Navia, MD

Role: backup

+57-3155643400

References

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Burrows HJ, Wilson JN, Scales JT. Excision of tumours of humerus and femur, with restoration by internal prostheses. J Bone Joint Surg Br. 1975 May;57(2):148-59.

Reference Type BACKGROUND
PMID: 1141281 (View on PubMed)

Ebeid W, Amin S, Abdelmegid A, Refaat Y, Ghoneimy A. Reconstruction of distal tibial defects following resection of malignant tumours by pedicled vascularised fibular grafts. Acta Orthop Belg. 2007 Jun;73(3):354-9.

Reference Type BACKGROUND
PMID: 17715726 (View on PubMed)

Liu T, Guo X, Zhang X, Li Z, Zhang Q. Reconstruction with pasteurized autograft for primary malignant bone tumor of distal tibia. Bull Cancer. 2012 Sep;99(9):87-91. doi: 10.1684/bdc.2012.1626.

Reference Type BACKGROUND
PMID: 22863837 (View on PubMed)

Ruggieri P, Angelini A, Jorge FD, Maraldi M, Giannini S. Review of foot tumors seen in a university tumor institute. J Foot Ankle Surg. 2014 May-Jun;53(3):282-5. doi: 10.1053/j.jfas.2014.01.015.

Reference Type BACKGROUND
PMID: 24751209 (View on PubMed)

Azevedo CP, Casanova JM, Guerra MG, Santos AL, Portela MI, Tavares PF. Tumors of the foot and ankle: a single-institution experience. J Foot Ankle Surg. 2013 Mar-Apr;52(2):147-52. doi: 10.1053/j.jfas.2012.12.004. Epub 2013 Jan 16.

Reference Type BACKGROUND
PMID: 23333280 (View on PubMed)

Zeytoonjian T, Mankin HJ, Gebhardt MC, Hornicek FJ. Distal lower extremity sarcomas: frequency of occurrence and patient survival rate. Foot Ankle Int. 2004 May;25(5):325-30. doi: 10.1177/107110070402500509.

Reference Type BACKGROUND
PMID: 15134614 (View on PubMed)

Clayer M, Doyle S, Sangha N, Grimer R. The toronto extremity salvage score in unoperated controls: an age, gender, and country comparison. Sarcoma. 2012;2012:717213. doi: 10.1155/2012/717213. Epub 2012 Sep 13.

Reference Type BACKGROUND
PMID: 23028240 (View on PubMed)

Ozger H, Eralp L, Turker M, Basaran M. Surgical treatment of malignant tumors of the foot and ankle. Int J Clin Oncol. 2005 Apr;10(2):127-32. doi: 10.1007/s10147-004-0470-9.

Reference Type BACKGROUND
PMID: 15864699 (View on PubMed)

Enneking WF, Dunham W, Gebhardt MC, Malawar M, Pritchard DJ. A system for the functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system. Clin Orthop Relat Res. 1993 Jan;(286):241-6.

Reference Type BACKGROUND
PMID: 8425352 (View on PubMed)

Other Identifiers

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000001

Identifier Type: -

Identifier Source: org_study_id

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