Trial of SK-1404 for Nocturia Due to Nocturnal Polyuria in Japanese Subjects

NCT ID: NCT03116191

Last Updated: 2018-04-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

125 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-02-23

Study Completion Date

2017-12-15

Brief Summary

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The purpose of this trial is to demonstrate efficacy of SK-1404 against placebo for the treatment of subjects with nocturia due to nocturnal polyuria, during 4 weeks of treatment.

Detailed Description

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Conditions

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Nocturia Due to Nocturnal Polyuria

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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SK-1404 high dose

Group Type EXPERIMENTAL

SK-1404

Intervention Type DRUG

4 weeks of repeated administration of SK-1404 to the patients of nocturia

SK-1404 middle dose

Group Type EXPERIMENTAL

SK-1404

Intervention Type DRUG

4 weeks of repeated administration of SK-1404 to the patients of nocturia

SK-1404 low dose

Group Type EXPERIMENTAL

SK-1404

Intervention Type DRUG

4 weeks of repeated administration of SK-1404 to the patients of nocturia

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

4 weeks of repeated administration of Placebo to the patients of nocturia

Interventions

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SK-1404

4 weeks of repeated administration of SK-1404 to the patients of nocturia

Intervention Type DRUG

Placebo

4 weeks of repeated administration of Placebo to the patients of nocturia

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* 5 \> nocturnal voids ≥2
* NPI \>0.33

Exclusion Criteria

* Polydipsia
* Cardiac failure
* Syndrome of inappropriate antidiuretic hormone secretion
* Hyponatraemia
* Uncontrolled diabetes mellitus
* Uncontrolled hypertension
* Moderate or severe over-active bladder (OAB)
* Severe benign prostate hyperplasia (BPH)
* Sleep apnoea
* Interstitial cystitis
* Stress urinary incontinence
* Diabetes insipidus
* Complication or a history of urological cancer
Minimum Eligible Age

55 Years

Maximum Eligible Age

79 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sanwa Kagaku Kenkyusho Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Investigational site (there may be other sites in this country)

Tokyo, , Japan

Site Status

Countries

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Japan

Other Identifiers

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VA1001

Identifier Type: -

Identifier Source: org_study_id

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