Study to Evaluate the Safety and Efficacy of DR-3001 Versus Placebo in Women With Overactive Bladder

NCT ID: NCT00196404

Last Updated: 2012-08-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

800 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-10-31

Study Completion Date

2006-12-31

Brief Summary

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This is a placebo-controlled, double-blind study to evaluate the safety and efficacy of two doses of DR-3001 in women with overactive bladder who have symptoms of predominant or pure urge incontinence, urinary urgency and elevated urinary frequency

Detailed Description

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This is a multi-center, randomized, placebo-controlled study to compare two doses of DR-3001 to placebo for a 12-week treatment period. The overall duration of patient participation will be for approximately 19 weeks. Patients will be required to keep a daily diary record of study medication use and incontinence episodes

Conditions

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Urinary Incontinence

Keywords

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overactive bladder urge incontinence urinary incontinence

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

Group Type EXPERIMENTAL

DR-3001a

Intervention Type DRUG

4mg daily vaginally

2

Group Type EXPERIMENTAL

DR-3001b

Intervention Type DRUG

6 mg vaginally daily

3

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Administered vaginally to match experimental arms

Interventions

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DR-3001a

4mg daily vaginally

Intervention Type DRUG

DR-3001b

6 mg vaginally daily

Intervention Type DRUG

Placebo

Administered vaginally to match experimental arms

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of overactive bladder and incontinence for at least 6 months
* Using birth control or menopausal
* Willing to discontinue current medication for overactive bladder

Exclusion Criteria

* Pregnant or given birth in the last 6 months
* Three or more urinary tract infections a year
* Uncontrolled glaucoma, hypertension, diabetes or myasthenia gravis
* History of bladder cancer, ulcerative colitis or severe constipation
* Any contraindication to vaginal delivery systems
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Duramed Research

INDUSTRY

Sponsor Role lead

Responsible Party

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Duramed Research, Inc

Principal Investigators

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Medical Monitor

Role: PRINCIPAL_INVESTIGATOR

Duramed Research

Locations

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Duramed Investigational Site

Birmingham, Alabama, United States

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Huntsville, Alabama, United States

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Mobile, Alabama, United States

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Phoenix, Arizona, United States

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Tucson, Arizona, United States

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Little Rock, Arkansas, United States

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San Diego, California, United States

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San Diego, California, United States

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Aurora, Colorado, United States

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Colorado Springs, Colorado, United States

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Denver, Colorado, United States

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Waterbury, Connecticut, United States

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Aventura, Florida, United States

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Gainesville, Florida, United States

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Decatur, Georgia, United States

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Sandy Springs, Georgia, United States

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Boise, Idaho, United States

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Boise, Indiana, United States

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Evansville, Indiana, United States

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Fort Wayne, Indiana, United States

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Indianapolis, Indiana, United States

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Jeffersonville, Indiana, United States

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Meridian, Indiana, United States

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Shreveport, Louisiana, United States

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Jackson, Mississippi, United States

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Lebanon, New Hampshire, United States

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Edison, New Jersey, United States

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Livingston, New Jersey, United States

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Moorestown, New Jersey, United States

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Williamsville, New York, United States

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Portland, Oregon, United States

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Lancaster, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Providence, Rhode Island, United States

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Charleston, South Carolina, United States

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Jackson, Tennessee, United States

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Memphis, Tennessee, United States

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Nashville, Tennessee, United States

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Dallas, Texas, United States

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Houston, Texas, United States

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San Antonio, Texas, United States

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Waco, Texas, United States

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Salt Lake City, Utah, United States

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Seattle, Washington, United States

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Tacoma, Washington, United States

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Milwaukee, Wisconsin, United States

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Vancouver, British Columbia, Canada

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Toronto, Ontario, Canada

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Countries

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United States Canada

References

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Stoniute A, Madhuvrata P, Still M, Barron-Millar E, Nabi G, Omar MI. Oral anticholinergic drugs versus placebo or no treatment for managing overactive bladder syndrome in adults. Cochrane Database Syst Rev. 2023 May 9;5(5):CD003781. doi: 10.1002/14651858.CD003781.pub3.

Reference Type DERIVED
PMID: 37160401 (View on PubMed)

Related Links

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Other Identifiers

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BR-OXY-202

Identifier Type: -

Identifier Source: org_study_id