Sebum Collection and Skin Barrier Function Analysis

NCT ID: NCT03112876

Last Updated: 2017-04-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

41 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-06-27

Study Completion Date

2016-02-26

Brief Summary

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The goal is this study is to evaluate how the skin surface lipid composition is correlated with overall sebum production, barrier function, and inflammatory disease status. We hypothesize that there will be differences in the skin surface composition among subjects of various groups:

1. Young vs older healthy population
2. Atopic dermatitis vs Acne vs Healthy controls
3. Active smokers vs non-smoker controls

Detailed Description

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This study will be conducted through the use of painless tapes to collect lipid. These will be applied to the skin and removed. Secondly, the barrier function will be evaluated through the use of non-invasive painless devices that measure sebum, skin water loss, and skin hydration.

Conditions

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Smoking Acne Atopic Dermatitis Aging

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Young Age - Healthy

These subjects are between the age of 12 and 35 years. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Skin Surface Lipid Collection and Skin Barrier Function

Intervention Type OTHER

All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Old Age -Healthy

These subjects are 55 years of age and older. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Skin Surface Lipid Collection and Skin Barrier Function

Intervention Type OTHER

All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Active Smoker

These subjects are active smokers who smoke often. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Skin Surface Lipid Collection and Skin Barrier Function

Intervention Type OTHER

All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Dermatological skin condition: Acne vulgaris

These subjects have acne vulgaris. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Skin Surface Lipid Collection and Skin Barrier Function

Intervention Type OTHER

All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Dermatological skin condition: Atopic dermatitis

These subjects have atopic dermatitis. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Skin Surface Lipid Collection and Skin Barrier Function

Intervention Type OTHER

All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Interventions

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Skin Surface Lipid Collection and Skin Barrier Function

All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Intervention Type OTHER

Other Intervention Names

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lipid profile sebum secretion rate skin water loss skin hydration

Eligibility Criteria

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Inclusion Criteria

* Subjects that are 12 years of age or older

Exclusion Criteria

* None
Minimum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of California, Davis

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Raja K Sivamani, MD

Role: PRINCIPAL_INVESTIGATOR

UC Davis

Locations

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UC Davis Department of Dermatology

Sacramento, California, United States

Site Status

Countries

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United States

References

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Ni Raghallaigh S, Bender K, Lacey N, Brennan L, Powell FC. The fatty acid profile of the skin surface lipid layer in papulopustular rosacea. Br J Dermatol. 2012 Feb;166(2):279-87. doi: 10.1111/j.1365-2133.2011.10662.x.

Reference Type BACKGROUND
PMID: 21967555 (View on PubMed)

Sakai S, Kikuchi K, Satoh J, Tagami H, Inoue S. Functional properties of the stratum corneum in patients with diabetes mellitus: similarities to senile xerosis. Br J Dermatol. 2005 Aug;153(2):319-23. doi: 10.1111/j.1365-2133.2005.06756.x.

Reference Type BACKGROUND
PMID: 16086742 (View on PubMed)

Related Links

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http://www.ucdmc.ucdavis.edu/dermatology/research/clinical

University of California-Davis Department of Dermatology Clinical Research

Other Identifiers

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605131

Identifier Type: -

Identifier Source: org_study_id

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