The Neural Correlates of Cannabis Use

NCT ID: NCT03104257

Last Updated: 2025-10-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

162 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-12-31

Study Completion Date

2022-04-27

Brief Summary

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The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed abstinence. This research will also examine associations between CB1R availability, neural oscillations and cognitive function.

Detailed Description

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The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed outpatient abstinence (confirmed by tracking creatinine adjusted urine THC-COOH levels). This research will also examine associations between CB1R availability, neural oscillations and cognitive function using \[11-C\]OMAR PET imaging and electroencephalography.

Conditions

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Cannabis Dependence Healthy

Study Design

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Observational Model Type

OTHER

Study Time Perspective

OTHER

Study Groups

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Cannabis Dependent Subjects

Subjects who are frequent cannabis users

[11-C]OMAR

Intervention Type DRUG

The radiotracer, \[11-C\]OMAR will be administered at no more than 10 micrograms at the beginning of each PET scan.

Healthy Controls

Subjects with no current cannabis use

[11-C]OMAR

Intervention Type DRUG

The radiotracer, \[11-C\]OMAR will be administered at no more than 10 micrograms at the beginning of each PET scan.

Interventions

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[11-C]OMAR

The radiotracer, \[11-C\]OMAR will be administered at no more than 10 micrograms at the beginning of each PET scan.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Current cannabis consumption
* Willing to abstain from cannabis use for four weeks


* No current cannabis consumption

Exclusion Criteria

* MRI metal exclusions and claustrophobia
* Education completed is less than 12 years
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute on Drug Abuse (NIDA)

NIH

Sponsor Role collaborator

Yale University

OTHER

Sponsor Role lead

Responsible Party

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Mohini Ranganathan

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mohini Ranganathan, MD

Role: PRINCIPAL_INVESTIGATOR

Yale University

Locations

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Conneticut Mental Health Center

New Haven, Connecticut, United States

Site Status

Countries

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United States

Other Identifiers

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1R01DA040698-01A1

Identifier Type: NIH

Identifier Source: secondary_id

View Link

1308012514

Identifier Type: -

Identifier Source: org_study_id

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