Cerebellar Alterations in Individuals With a Cannabis Use Disorder
NCT ID: NCT02816034
Last Updated: 2018-11-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
32 participants
INTERVENTIONAL
2016-06-30
2017-04-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Experimental Explicit
Cannabis user performs visuo-motor rotation tasks informed of an explicit strategy to maximise performance
Visuo-motor rotation
Participant moves a cursor on a screen by sliding a pen over a digital tablet. Participants perform a center-out movement, aiming to a target that appears over one of a set of eight markers radially distributed. In several block of trials, the mapping of the pen position to the cursor is rotated.
Explicit strategy
Participant is provided with an explicit instruction as to how counteract the effects of the visuo-motor rotation via aiming to a marker adjacent target
Control Explicit
Healthy subject performs visuo-motor rotation tasks informed of an explicit strategy to maximise performance
Visuo-motor rotation
Participant moves a cursor on a screen by sliding a pen over a digital tablet. Participants perform a center-out movement, aiming to a target that appears over one of a set of eight markers radially distributed. In several block of trials, the mapping of the pen position to the cursor is rotated.
Experimental Implicit
Cannabis user performs visuo-motor rotation tasks without being informed of the explicit strategy
Visuo-motor rotation
Participant moves a cursor on a screen by sliding a pen over a digital tablet. Participants perform a center-out movement, aiming to a target that appears over one of a set of eight markers radially distributed. In several block of trials, the mapping of the pen position to the cursor is rotated.
Explicit strategy
Participant is provided with an explicit instruction as to how counteract the effects of the visuo-motor rotation via aiming to a marker adjacent target
Control Implicit
Healthy subject performs visuo-motor rotation tasks without being informed of the explicit strategy
Visuo-motor rotation
Participant moves a cursor on a screen by sliding a pen over a digital tablet. Participants perform a center-out movement, aiming to a target that appears over one of a set of eight markers radially distributed. In several block of trials, the mapping of the pen position to the cursor is rotated.
Interventions
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Visuo-motor rotation
Participant moves a cursor on a screen by sliding a pen over a digital tablet. Participants perform a center-out movement, aiming to a target that appears over one of a set of eight markers radially distributed. In several block of trials, the mapping of the pen position to the cursor is rotated.
Explicit strategy
Participant is provided with an explicit instruction as to how counteract the effects of the visuo-motor rotation via aiming to a marker adjacent target
Eligibility Criteria
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Inclusion Criteria
* Patients screen positive to cannabis in the urine analysis performed a week prior to assessment.
* Right-handed patients.
* Patients provide a signed consent.
Exclusion Criteria
* Patients with a visual impairment that has not been corrected.
* Patients with a cognitive impairment such as mental retardation.
* Patients with psychotic disorders.
18 Years
50 Years
ALL
Yes
Sponsors
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Hospital Clinic of Barcelona
OTHER
Institut d'Investigacions Biomèdiques August Pi i Sunyer
OTHER
Universitat Pompeu Fabra
OTHER
Responsible Party
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Paul Verschure
Professor
References
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Taylor JA, Klemfuss NM, Ivry RB. An explicit strategy prevails when the cerebellum fails to compute movement errors. Cerebellum. 2010 Dec;9(4):580-6. doi: 10.1007/s12311-010-0201-x.
Mazzoni P, Krakauer JW. An implicit plan overrides an explicit strategy during visuomotor adaptation. J Neurosci. 2006 Apr 5;26(14):3642-5. doi: 10.1523/JNEUROSCI.5317-05.2006.
Other Identifiers
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CannabinoidsCerebellum
Identifier Type: -
Identifier Source: org_study_id
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