Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 3
NCT ID: NCT06669585
Last Updated: 2024-12-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
64 participants
OBSERVATIONAL
2024-10-09
2026-01-31
Brief Summary
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Detailed Description
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This study tests the effects of commercially available cannabis flower strains on recognition memory performance and ERPs that are related to different underlying memory processes in healthy, regular cannabis users. An episodic memory task is used to assess recognition memory, which asks participants to discriminate between previously studied and non-studied items using pictures as stimuli. Participants complete the same memory task while intoxicated one day and not intoxicated another day. A THC-dominant strain and a strain containing both THC and CBD are included in the study. Participants self-administer one of the two cannabis strains prior to memory encoding and retrieval.
Blood is collected to determine THC and CBD exposure, as well as to explore how genetic variation in genes related to cannabinoid metabolism, cannabis-related behavior, and neurocognitive function associate with memory function before and after cannabis use. Participants also complete self-report measures of medical history, sleep quality, subjective cognitive function, physical activity, psychological functioning, substance use, and acute drug effects.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Interventions
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Cannabis (smoked flower)
Self-Directed Use (ad-libitum)
Eligibility Criteria
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Inclusion Criteria
2. Must be right-handed (Laterality Quotient \> 60 on Edinburgh Handedness Inventory - Short Form);
3. Must use cannabis at least 4 days during the month;
4. Must be a cannabis user for at least a year;
5. Must self-report not using other illicit recreational drugs (e.g., cocaine, benzodiazepines (non-prescription), opiates (non-prescription), MDMA, sedatives, or methamphetamine) in the past 30 days, during the Pre-Screening;
6. Must not test positive on a urine toxicology test for drugs of abuse at the Baseline appointment;
7. Must not be using psychotropic medications, however anti-depressant, non-benzodiazepine anti-anxiety, and ADHD medications are ok. ADHD medication users must be willing to abstain from ADHD medication use on appointment days;
8. Must not be a regular nicotine user (≤4 days per week; cigarette, E-cigs, or smokeless);
9. Must not have used caffeine or nicotine (cigarette, E-cigs, or smokeless) for 4 hours before each appointment;
10. Must have a breath alcohol level of 0 at Baseline appointment (to sign consent form);
11. Must not be actively seeking or in treatment for any substance use disorder;
12. Female subjects must not be or trying to become pregnant (as indicated by a pregnancy test administered at Baseline appointment);
13. Must not be in treatment for psychotic disorder or bipolar disorder; or have a history with these disorders;
14. Must not have any physical characteristics (e.g., thick hair, head size exceeding the limit of the net, dyed hair) or experience any technical difficulties during testing that result in a poor-quality EEG recording.
21 Years
40 Years
ALL
Yes
Sponsors
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National Institute on Drug Abuse (NIDA)
NIH
L. Cinnamon Bidwell
OTHER
Responsible Party
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L. Cinnamon Bidwell
Associate Professor
Principal Investigators
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Timothy Curran, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Colorado, Boulder
Locations
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Center for Innovation and Creativity (CINC)
Boulder, Colorado, United States
Countries
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Central Contacts
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Facility Contacts
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Katie N Paulich, PhD
Role: primary
Timothy Curran, PhD
Role: backup
Related Links
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CUChange Study Website
Other Identifiers
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20-0309: Experiment 3
Identifier Type: -
Identifier Source: org_study_id