FLNA in HCC Patients

NCT ID: NCT03081637

Last Updated: 2017-06-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

115 participants

Study Classification

OBSERVATIONAL

Study Start Date

2004-01-01

Study Completion Date

2017-03-02

Brief Summary

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The risk of recurrence after hepatectomy for hepatocellular carcinoma (HCC) is very high. Having a predictive marker of early recurrence (ER) would be desirable to personalize the follow-up and possibly develop new targeted therapy. The aim of this study was to test the expression of Filamin A (FLNA) in a cohort of patients operated for HCC.

Detailed Description

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A consecutive cohort of resected HCC patients will be analyzed. Several different prognostic factors, including FLNA expression, will be tested against the risk of ER. FLNA expression will be analyzed with immunohistochemistry in the intra-tumoral and extra-tumoral tissue compartments using a dedicated tissue microarray.

Conditions

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Hepatocellular Carcinoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Exclusion Criteria

* Patients preoperatively treated with chemotherapy or trans-arterial therapy were excluded.
* Similarly, patients operated for recurrent HCC or with non-radical surgery or with missing data were excluded.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Milan

OTHER

Sponsor Role lead

Responsible Party

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Prof. Guido Torzilli

Professor of Surgery, Director Department of Hepatobiliary and General Surgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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FLNA in HCC

Identifier Type: -

Identifier Source: org_study_id

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