Estimation of Functional Liver Reserve Using Cholinesterases

NCT ID: NCT00883454

Last Updated: 2009-04-17

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 181 participants
• Study Classification: OBSERVATIONAL

Brief Summary

Estimation of functional liver reserve in patients with hepatocellular carcinoma (HCC) in cirrhosis is of paramount importance to properly select candidates for surgical resection. Together with the value of bilirubin, the presence/absence of ascites and esophageal varices, and the rate of residual liver volume, which are our current parameters to measure functional liver reserve, the investigators sought to investigate the value of preoperative cholinesterases (CHE) in predict postoperative adverse outcome after hepatic resection for HCC.

Conditions

Hepatocellular Carcinoma; Cirrhosis; Liver Neoplasm; Liver Disease

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Eligibility Criteria

Inclusion Criteria

1. Total bilirubin < 2 mg/dl

2. No ascites

3. No esophageal varices, or esophageal varices eradicated by endoscopy

4. Liver volume:

• residual liver volume > or = 40% if total bilirubin < 1 mg/dl
• residual liver volume > or = 50% if total bilirubin between 1 and 1.5 mg/dl
• only limited resection if total bilirubin > 1.5 mg/dl

5. Portal vein embolization was selected in any case in whom RLV did not fit the previous requirements.

Exclusion Criteria

1. Total bilirubin > 2 mg/dl

2. Refractory ascites

3. Esophageal varices

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Milan

OTHER

Sponsor Role: lead

Locations

Liver Surgery Unit, Third Department of Surgery, University of MIlan, IRCCS Istituto Clinico Humanitas

Rozzano, Milan, Milan, Italy

Countries

Italy

Other Identifiers

CHE-HCC

Identifier Type: -

Identifier Source: org_study_id