Liver Fat Quantification by Magnetic Resonance Imaging (MRI) - Prediction of Postoperative Complications

NCT ID: NCT01234714

Last Updated: 2012-02-08

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

84 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-10-31

Study Completion Date

2011-07-31

Brief Summary

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The purpose of this study is to objectively quantify liver fat content (LFC) by Magnetic Resonant Imaging (MRI) prior to major liver surgery, and to investigate its association with post-operative complications.

Detailed Description

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Lack of agreement exists among expert pathologists in the standard histological assessment of hepatic steatosis on biopsy. The impact of different grades of steatosis on postoperative complications after major liver resection remains controversial.

Conditions

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Fatty Liver Surgery

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Major liver resection

This single Cohort/Group will include all consecutive patients that received pre-operative Magnetic Resonant Imaging (MRI) and underwent major liver resection (\>=3 segments).

Non-invasive Magnetic Resonance Imaging (MRI)

Intervention Type OTHER

Conventional pre-operative MRI

Major liver resection

Intervention Type PROCEDURE

Hepatectomy of \>= 3 liver segments

Interventions

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Non-invasive Magnetic Resonance Imaging (MRI)

Conventional pre-operative MRI

Intervention Type OTHER

Major liver resection

Hepatectomy of \>= 3 liver segments

Intervention Type PROCEDURE

Other Intervention Names

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Magnetic Resonance Imaging Hepatectomy = liver resection by open surgery.

Eligibility Criteria

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Inclusion Criteria

* Major liver resection (\>= 3 resected segments).
* Patients that received a pre-operative Magnetic Resonance Imaging (MRI).
* Patient over 18 years of age

Exclusion Criteria

* Patients that underwent liver surgery but \< 3 segments were resected (e.g. wedge liver resection).
* Patient that did not receive a pre-operative MRI
* Patient age less than 18 years of age.
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Zurich

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dimitri A Raptis, MD, MSc

Role: PRINCIPAL_INVESTIGATOR

University Hospital Zurich, Department of Visceral and Transplant Surgery, Zurich, Switzerland

Locations

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University Hospital Zurich, Department of Interventional and Diagnostic Radiology

Zurich, Canton of Zurich, Switzerland

Site Status

University Hospital Zurich, Department of Visceral and Transplant Surgery, Swiss Hepato-Pancreato-Biliary (HPB) Center

Zurich, Canton of Zurich, Switzerland

Site Status

Countries

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Switzerland

References

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Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, de Santibanes E, Pekolj J, Slankamenac K, Bassi C, Graf R, Vonlanthen R, Padbury R, Cameron JL, Makuuchi M. The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg. 2009 Aug;250(2):187-96. doi: 10.1097/SLA.0b013e3181b13ca2.

Reference Type BACKGROUND
PMID: 19638912 (View on PubMed)

Raptis DA, Fischer MA, Graf R, Nanz D, Weber A, Moritz W, Tian Y, Oberkofler CE, Clavien PA. MRI: the new reference standard in quantifying hepatic steatosis? Gut. 2012 Jan;61(1):117-27. doi: 10.1136/gutjnl-2011-300155. Epub 2011 Oct 13.

Reference Type RESULT
PMID: 21997548 (View on PubMed)

Other Identifiers

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MRI_Steatosis_Outcomes

Identifier Type: -

Identifier Source: org_study_id

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