EPIPAGE2 Cohort Study Follow up at Five and a Half Years
NCT ID: NCT03078439
Last Updated: 2025-12-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
3404 participants
OBSERVATIONAL
2016-09-02
2018-01-08
Brief Summary
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These children are being studied from their birth up to the age of 12 years. At birth, data on maternal and infants' characteristics were collected from medical records. At one and two years, questionnaires sent to families and to physicians (at two years only) allowed to collect data about the children's life and health.
At five and a half years, medical and psychological assessments are specifically implemented for the study in order to evaluate motor and cognitive disorders in this population.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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Medical and neuropsychological assessments
Assessment of health status and development will be performed in specific centers at 5 and a half years. This check-up includes a complete medical examination to look for visual, hearing, motor impairment and health problems, and psychological tests using standardized tools (WPPSI IV ((Wechsler Preschool and Primary Scales Intelligence)) and NEPSY 2 tests) to assess cognitive development of very preterm children.
A parental questionnaire will be fulfilled to investigate family's social conditions, maternal health, autism spectrum disorders (Social Communication Questionnaire), the child's quality of life and behavioral development (Strengths and Difficulties Questionnaire).
Eligibility Criteria
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Inclusion Criteria
* family agreement to participate to cohort follow up
* informed consent form signed by both parents
* affiliated to social security system
Exclusion Criteria
* not affiliated to any social security system
5 Years
6 Years
ALL
No
Sponsors
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Institut National de la Santé Et de la Recherche Médicale, France
OTHER_GOV
Responsible Party
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Locations
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Hôpital de Forbach
Forbach, , France
Centre Hopsitalier d'Agen
Agen, , France
CAMSP Albi
Albi, , France
CHU Amiens
Amiens, , France
CHU d'Angers
Angers, , France
CH d'Arras
Arras, , France
CAMSP Auch
Auch, , France
Centre Hospitalier Côte Basque
Bayonne, , France
CH Beauvais
Beauvais, , France
CHU Jean Minjoz
Besançon, , France
Centre Hospitalier de Bordeaux
Bordeaux, , France
CH Bourg en Bresse
Bourg-en-Bresse, , France
CHU de Brest
Brest, , France
Rezo Camsp
Brioude, , France
Hopital Femme, Mère, Enfant
Bron, , France
CHU de Caen
Caen, , France
CH Cahors
Cahors, , France
CMPP de Cahors
Cahors, , France
CH de Calais
Calais, , France
CH de Carcassonne
Carcassonne, , France
CH Castres - Hôpital du pays d'Autan
Castres, , France
CH Chalon sur Saone - William Morey
Chalon-sur-Saône, , France
Réseau Eclaur
Chambéry, , France
CH Métropole Savoie
Chambéry, , France
CAMSP de Charleville Mézières
Charleville-Mézières, , France
CHU Estaing
Clermont-Ferrand, , France
Centre Hospitalier de Colmar
Colmar, , France
CH Compiègne
Compiègne, , France
CH Alpes Leman
Contamine-sur-Arve, , France
CH Sud Francilien
Corbeil, , France
CH Creil
Creil, , France
CAMSP de Dax
Dax, , France
CHU Dijon - Hôpital du Bocage
Dijon, , France
CH de Douai
Douai, , France
CAMSP Espaly
Espaly-Saint-Marcel, , France
SCM Maison de l'enfant
Essey-lès-Nancy, , France
Hôpital d'Epinal
Épinal, , France
CHU Grenoble / Réseau Naitre et Devenir
Grenoble, , France
Centre Hospitalier de Haguenau
Haguenau, , France
CH Laon
Laon, , France
CHU Le Mans
Le Mans, , France
CH de Lens
Lens, , France
Hôpital Saint Vincent de Paul - Groupement des Hôpitaux de l'Institut Catholique de Lille
Lille, , France
CHRU de Lille
Lille, , France
Hôpital Mère-Enfant de Limoges
Limoges, , France
CAMSP, CHU de Lorient
Lorient, , France
Hopital de la Croix Rousse
Lyon, , France
CHU Hôpital Nord
Marseille, , France
CHU de la Conception
Marseille, , France
CH de Maubeuge
Maubeuge, , France
CH Mâcon
Mâcon, , France
Hôpital de Mercy - CHR Metz Thionville
Metz, , France
CH Annecy Genevois
Metz-Tessy, , France
Centre Hospitalier de Mont de Marsan
Mont-de-Marsan, , France
CAMSP "l'Escabelle" Montauban
Montauban, , France
CH Montauban
Montauban, , France
GHH Havre - Hôpital Jacque Monod
Montivilliers, , France
CHU de Montpellier
Montpellier, , France
CAMSP - CHU Saint-Eloi
Montpellier, , France
Centre Hospitalier de Mulhouse
Mulhouse, , France
CHRU de Nancy (Maternité)
Nancy, , France
CHRU de Nancy (Neuro-pédiatrie)
Nancy, , France
CHU de Nantes
Nantes, , France
CHU Hôpital l'Archet
Nice, , France
CHU de Nimes - Hôpital Caremeau
Nîmes, , France
CHR Orléans
Orléans, , France
Hôpital Armand Trousseau
Paris, , France
CIC Necker
Paris, , France
Centre Hospitalier de Pau
Pau, , France
CHG de Perpignan (CAMSP)
Perpignan, , France
CAMSP de Périgueux
Périgueux, , France
CHU de Reims / CAMSP
Reims, , France
CAMSP, CHU de Rennes
Rennes, , France
CH Rodez - Jacques Puel
Rodez, , France
CH de Roubaix
Roubaix, , France
CHU de Rouen - Pavillon Mère et enfant
Rouen, , France
CAMSP de Saint Brieuc
Saint-Brieuc, , France
CHU Sud Réunion
Saint-Pierre, , France
CHU St Etienne / Réseau HELENA
Saint-Priest-en-Jarez, , France
CH Saint Quentin
Saint-Quentin, , France
Centre Hospitalier Hautepierre
Strasbourg, , France
CH de Bigorre
Tarbes, , France
CAMSP Thionville
Thionville, , France
Hôpital Bel Air Thionville - CHR Metz Thionville
Thionville, , France
CHU de Toulouse - Hôpital des enfants
Toulouse, , France
Clinique Ambroise Paré
Toulouse, , France
CHRU de Tours -Hôpital Clocheville
Tours, , France
CAMSP de Troyes
Troyes, , France
CH Valence
Valence, , France
CH de Valenciennes
Valenciennes, , France
CH de Vannes
Vannes, , France
CH Villefranche sur Saone
Villefranche-sur-Saône, , France
CH Andrée Rosemon
Cayenne, , French Guiana
CH de l'Ouest Guyanais
Saint-Laurent-du-Maroni, , French Guiana
CAMSP Basse-Terre
Basse-Terre, , Guadeloupe
CHU Pointre à Pitre
Les Abymes, , Guadeloupe
CAMSP Nord-ASFA Sainte Clotilde
Saint-Denis, , Reunion
CHU Felix Guyon
Saint-Denis, , Reunion
Countries
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References
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Guellec I, Brunet A, Lapillonne A, Taine M, Torchin H, Favrais G, Gascoin G, Simon L, Heude B, Scherdel P, Kayem G, Delorme P, Jarreau PH, Ancel PY. Birth weight and head circumference discordance and outcome in preterms: results from the EPIPAGE-2 cohort. Arch Dis Child. 2024 May 17;109(6):503-509. doi: 10.1136/archdischild-2023-326336.
Related Links
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Epipage 2 website
Other Identifiers
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IDRCB
Identifier Type: REGISTRY
Identifier Source: secondary_id
C15-95
Identifier Type: -
Identifier Source: org_study_id
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