Follow-up During the Peripubertal Period of Preterm Children Included in the Protocol Entitled "EPIPOD".

NCT ID: NCT04945369

Last Updated: 2025-11-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

114 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-02-02

Study Completion Date

2028-02-02

Brief Summary

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Prematurity is associated with an increased risk of developing cardiovascular and metabolic disturbances in adulthood.

It has been demonstrated that the body composition of children born prematurely is different from that of children born under term with a deficit in fat free mass.

It can thus be wondered if this excessive adiposity does or does not predict the risk of insulin resistance in adulthood.

Children born prematurely, with a body composition measurement performed at discharge from neonatal hospitalization as part of the EPIPOD protocol, and now aged between 8 and 14 years, will be included in the INFANTPOD protocol.

Analysis of body composition, insulin resistance, renal function, pulse wave velocity, eating behaviour and of physical activity will be performed.

Detailed Description

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Conditions

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Preterm Children

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Children born prematurely included in the EPIPOD protocol and now in the peripubertal period

At inclusion in the INFANTPOD study :

* Blood and urinary samples collection for evaluation of insulin resistance and of renal function analysis.
* Assessment of body composition by a commercialized device called "BOP-POD" and by impedancemetry
* Assessment of pulse wave by a commercialized device called "popmetre"
* Questionnaires for analysis of eating behaviour
* Assessment of physical activity by a commercialized device called "accelerometer" and by questionnaire.

Group Type EXPERIMENTAL

clinical and biological measurements and questionnaires

Intervention Type OTHER

Blood and urinary samples collection for evaluation of insulin resistance and of renal function analysis.

Assessment of body composition by BOP-POD and by impedancemetry. Assessment of pulse wave by popmetre. Assessment of physical activity by accelerometer and by questionnaire Questionnaires for analysis of eating behaviour

Interventions

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clinical and biological measurements and questionnaires

Blood and urinary samples collection for evaluation of insulin resistance and of renal function analysis.

Assessment of body composition by BOP-POD and by impedancemetry. Assessment of pulse wave by popmetre. Assessment of physical activity by accelerometer and by questionnaire Questionnaires for analysis of eating behaviour

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Children hospitalised at the Nantes University Hospital in the neonatal period
* With a body composition measurement performed at discharge from neonatal hospitalization as part of the EPIPOD protocol
* Born prematurely (under 35 weeks of amenorrhea)
* Included in the Lift cohort with follow-up up to 7 years
* Aged between 8 and 14 years at inclusion

Exclusion Criteria

* Children with an isolated metabolic disease: insulin-dependent diabetes; endocrine disease (Cushing's, hypothyroidism)
* Age of 15 years or more
* with a chromosomal anomaly
* with contraindicating measurement of the BOP-POD: ventilatory support, continuous parenteral feeding, elimination stoma
* Refusal of either parent or child
Minimum Eligible Age

8 Years

Maximum Eligible Age

14 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nantes University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Nantes University Hospital

Nantes, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Anne FRONDAS, Doctor

Role: CONTACT

Phone: +33 2 40 08 34 83

Email: [email protected]

Facility Contacts

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Anne FRONDAS, Doctor

Role: primary

Other Identifiers

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RC20_0522

Identifier Type: -

Identifier Source: org_study_id