Nutrition and Neurological Development of Very Preterm Infants

NCT ID: NCT02184650

Last Updated: 2025-11-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

206 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-07-31

Study Completion Date

2017-12-31

Brief Summary

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The main goal of this study is to determine, in preterm infants born with a GA \< 32 weeks, the association between:

* the quantity of mother's milk and duration and breastfeeding
* the intake of polyunsaturated fatty acids and iron during hospitalizations

Detailed Description

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The main hypothesis of this study is that the intake of lipid during hospitalization in neonatology department is associated with neurological development of preterm infants born with a GA \< 32 weeks. The other hypotheses are that iron intake and the duration of breastfeeding are also associated with the development of preterm infants.

In the previous study EPINUTRI (NCT01486173), the development of infants was evaluated until the age of 1 year. EPINUTRI\_3 is the follow-up of EPINUTRI until the age of 3 years.

The aim of EPINUTRI\_3 study is to determine the association between lipid intake during hospitalization in neonatology department of preterm infants born with a GA \< 32 weeks.

The secondary objective is :

\- to evaluate the association between these factors and communication, developmental and social-emotional delays with the test " Ages and Stages questionnaire " (ASQ) at 3 years of age.

Conditions

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Premature Infant Infant Nutrition Disorders Delayed Mental Development

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Premature infants

Premature infants with a GA \< 32 weeks

Premature infants with a GA < 32 weeks

Intervention Type OTHER

At 3 years of age: ASQ (filled in by parents)

Interventions

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Premature infants with a GA < 32 weeks

At 3 years of age: ASQ (filled in by parents)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Premature infants previously included in EPINUTRI study
* Non opposition of the parents for the collection of clinical and nutritional data

Exclusion Criteria

* Refusal of the parents to collect clinical and nutritional data
Minimum Eligible Age

3 Years

Maximum Eligible Age

3 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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URC-CIC Paris Descartes Necker Cochin

OTHER

Sponsor Role collaborator

Assistance Publique - Hôpitaux de Paris

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Alexandre Lapillonne, M.D, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Hôpital Necker Assistance Publique-Hôpitaux de Paris

Locations

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Hôpital Necker Assistance Publique- Hôpitaux de Paris

Paris, , France

Site Status

Countries

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France

References

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Pierrat V, Marchand-Martin L, Marret S, Arnaud C, Benhammou V, Cambonie G, Debillon T, Dufourg MN, Gire C, Goffinet F, Kaminski M, Lapillonne A, Morgan AS, Roze JC, Twilhaar S, Charles MA, Ancel PY; EPIPAGE-2 writing group. Neurodevelopmental outcomes at age 5 among children born preterm: EPIPAGE-2 cohort study. BMJ. 2021 Apr 28;373:n741. doi: 10.1136/bmj.n741.

Reference Type RESULT
PMID: 33910920 (View on PubMed)

Other Identifiers

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ID RCB 2014-A00941-46

Identifier Type: OTHER

Identifier Source: secondary_id

NI 13016

Identifier Type: -

Identifier Source: org_study_id

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