Pharmacokinetic Study to Compare Absorption of Budesonide/Formoterol Easyhaler and Symbicort Turbuhaler

NCT ID: NCT03073057

Last Updated: 2017-03-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-01-31

Study Completion Date

2016-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to compare Budesonide/formoterol Easyhaler test products with the marketed product Symbicort Turbuhaler in terms of the drug absorbed into the bloodstream.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Asthma

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Charcoal and Budesonide/formoterol Easyhaler A

160/4.5microg/inhalation Charcoal

Group Type EXPERIMENTAL

Budesonide/formoterol

Intervention Type DRUG

2 inhalations as a single dose

Charcoal

Intervention Type OTHER

Charcoal and Budesonide/formoterol Easyhaler B

160/4.5microg/inhalation Charcoal

Group Type EXPERIMENTAL

Budesonide/formoterol

Intervention Type DRUG

2 inhalations as a single dose

Charcoal

Intervention Type OTHER

Charcoal and Budesonide/formoterol Easyhaler C

160/4.5microg/inhalation Charcoal

Group Type EXPERIMENTAL

Budesonide/formoterol

Intervention Type DRUG

2 inhalations as a single dose

Charcoal

Intervention Type OTHER

Charcoal and Symbicort Turbuhaler

160/4.5microg/inhalation Charcoal

Group Type ACTIVE_COMPARATOR

Charcoal

Intervention Type OTHER

Symbicort Turbuhaler

Intervention Type DRUG

2 inhalations as a single dose

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Budesonide/formoterol

2 inhalations as a single dose

Intervention Type DRUG

Charcoal

Intervention Type OTHER

Symbicort Turbuhaler

2 inhalations as a single dose

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Budesonide/formoterol 160/4.5microg Symbicort Turbuhaler 160/4.5 microg

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Written informed consent obtained
* Body mass index \> 19 and \< 30kg/m2, weight at least 50 kg
* Good general health ascertained by detailed medical history, and laboratory and physical examinations

Exclusion Criteria

* Evidence of a clinically significant cardiovascular, renal, hepatic, haematological, GI, pulmonary, metabolic-endocrine, neurological or psychiatric disease
* Any condition requiring regular concomitant treatment (including vitamins and herbal products) or likely to need any concomitant treatment during a study.
* Known hypersensitivity to the active substance(s) or the excipient of the drug
* Pregnant and lactating females
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Orion Corporation, Orion Pharma

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Iissa Kivisto

Role: STUDY_DIRECTOR

Orion Corporation, Orion Pharma

Leena Mattila, MD

Role: PRINCIPAL_INVESTIGATOR

Orion Pharma, Clinical Pharmacology Unit, Espoo, Finland

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Orion Pharma, Clinical Pharmacology Unit

Espoo, , Finland

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Finland

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

3103014

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.