Anorectal Function and Neuronal-glial-epithelial Unit in Healthy Subjects
NCT ID: NCT03054415
Last Updated: 2019-12-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
16 participants
INTERVENTIONAL
2017-05-05
2020-02-05
Brief Summary
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The enteric nervous system (ENS) is composed by enteric neurons and enteric glial cells. There is a cross-talk between ENS and the intestinal epithelial barrier (IEB). ENS and IEB together constitute the neuronal-glial-epithelial unit. This unit has a key role in gut functions. The characteristics and the phenotype of the ENS also change according to age and environmental factors. Similar study is ongoing for patients with Spina Bifida. Anorectal data and phenotype of the neuronal-glial-epithelial unit in healthy subjects is required to assess abnormality of these items in patients with neurological disease including Spina Bifida.
Detailed Description
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Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
OTHER
NONE
Study Groups
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Healthy Subjects
endoscopy
colonic biopsies during endoscopy and anal manometry with barostat and anal endoflip
Interventions
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endoscopy
colonic biopsies during endoscopy and anal manometry with barostat and anal endoflip
Eligibility Criteria
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Inclusion Criteria
* subject who gave their written consent to participate to the present study
* subject not included in another study
* subject covered by social insurance system
Exclusion Criteria
* Anticoagulants therapy or coagulation disorders;
* Past history of anal or rectal surgery
* Crohn disease or ulcerative colitis
* Irritable bowel syndrome according to the Rome III criteria;
* Past history of pelvic radiotherapy
* Pas history of rectal or anal cancer
* Anorectal symptoms : faecal incontinence, constipation, anorectal pain, rectal prolapse;
* CCIS \>5 (faecal incontinence);
* Kess Score \>9 (constipation);
* Colonic irrigation;
* Use of laxatives;
* Abnormal colonic mucosa
* Period of exclusion;
* Patient under guardianship or unable to give their consent;
18 Years
65 Years
ALL
Yes
Sponsors
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Rennes University Hospital
OTHER
Responsible Party
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Principal Investigators
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Charlène BROCHARD, Md
Role: PRINCIPAL_INVESTIGATOR
Rennes University Hospital
Locations
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Rennes University Hospital
Rennes, , France
Countries
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References
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Lefevre C, Le Roy C, Bessard A, Le Berre-Scoul C, Marchix J, Coron E, Le Rhun M, Brochard C, Perrouin-Verbe B, Neunlist M. Region-specific remodeling of the enteric nervous system and enteroendocrine cells in the colon of spinal cord injury patients. Sci Rep. 2023 Oct 6;13(1):16902. doi: 10.1038/s41598-023-44057-y.
Brochard C, Bouguen G, Olivier R, Durand T, Henno S, Peyronnet B, Pagenault M, Lefevre C, Boudry G, Croyal M, Fautrel A, Esvan M, Ropert A, Dariel A, Siproudhis L, Neunlist M. Altered epithelial barrier functions in the colon of patients with spina bifida. Sci Rep. 2022 May 3;12(1):7196. doi: 10.1038/s41598-022-11289-3.
Other Identifiers
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2016-A01541-50
Identifier Type: -
Identifier Source: org_study_id