French Colorectal ESD Cohort in Experts Centers

NCT ID: NCT04592003

Last Updated: 2025-09-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-01

Study Completion Date

2026-01-01

Brief Summary

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Initially developed in Japan for the treatment of endemic superficial gastric cancers, endoscopic submucosal dissection (ESD) allows resection of pre-neoplastic and neoplastic lesions of the digestive tract into a single fragment. It allows a perfect pathological analysis, and decreases the rate of recurrence of the adenoma to less than 2%. However, this procedure, which is technically more challenging, is also more risky (perforation rate at 4% vs. 1% for WF-EMR) and longer. Submucosal dissection is also more expensive in terms of equipment, but this difference can be offset by the cost of the high number of iterative colonoscopies required in patients who have had endoscopic resection by WF-EMR.

Scientific debate is agitating the Western world1,2 and Japanese experts do not perform WF-EMR anymore, whereas no comparative prospective study has compared these two procedures.

A lot of centers in France performed colorectal ESD even for benign lesions and nationwide data about safety and efficiency is required to confirm the place of ESD for treatment of large superficial colorectal lesions.

The aim of this French multicenter cohort is to analyze the results of colorectal submucosal dissection on a large scale.

Detailed Description

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Initially developed in Japan for the treatment of endemic superficial gastric cancers, endoscopic submucosal dissection (ESD) allows resection of pre-neoplastic and neoplastic lesions of the digestive tract into a single fragment. It allows a perfect pathological analysis, and decreases the rate of recurrence of the adenoma to less than 2%. However, this procedure, which is technically more challenging, is also more risky (perforation rate at 4% vs. 1% for WF-EMR) and longer. Submucosal dissection is also more expensive in terms of equipment, but this difference can be offset by the cost of the high number of iterative colonoscopies required in patients who have had endoscopic resection by WF-EMR.

Scientific debate is agitating the Western world1,2 and Japanese experts do not perform WF-EMR anymore, whereas no comparative prospective study has compared these two procedures.

A lot of centers in France performed colorectal ESD even for benign lesions and nationwide data about safety and efficiency is required to confirm the place of ESD for treatment of large superficial colorectal lesions.

The aim of this French multicenter cohort is to analyze the results of colorectal submucosal dissection on a large scale.

Conditions

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Cancer Colorectal Polyps Colorectal Endoscopic Submucosal Resection

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Study Groups

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FECCo : French Esd Colorectal Cohort in Experts Centers

All patients over 18 years of age referred for submucosal dissection of a polyp or a colorectal LST in the French centers participating in the cohort.

Endoscopic submucosal dissection

Intervention Type PROCEDURE

Endoscopic submucosal dissection

Interventions

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Endoscopic submucosal dissection

Endoscopic submucosal dissection

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

All patients addressed for a colorectal ESD

Exclusion Criteria

Opposition notified in the context of a non-opposition form after reading the information notice
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Limoges

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jérémie Jacques, Pr

Role: PRINCIPAL_INVESTIGATOR

Service d'Hépato-Gastro-Entérologie et Nutrition du CHU de LIMOGES

Locations

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CHU d'Amiens

Amiens, , France

Site Status RECRUITING

Clinique de l'Anjou

Angers, , France

Site Status RECRUITING

CHU de Besançon

Besançon, , France

Site Status RECRUITING

CHU de Bordeaux

Bordeaux, , France

Site Status RECRUITING

CHRU de Brest

Brest, , France

Site Status RECRUITING

CHU de Dijon

Dijon, , France

Site Status RECRUITING

CHU de Limoges

Limoges, , France

Site Status RECRUITING

Hopital Edouard Herriot

Lyon, , France

Site Status RECRUITING

Hôpital Jean Mermoz

Lyon, , France

Site Status RECRUITING

Hôpital Européen

Marseille, , France

Site Status RECRUITING

CHU de Montpellier

Montpellier, , France

Site Status RECRUITING

CHU de Nancy

Nancy, , France

Site Status RECRUITING

Clinique Jules Vernes

Nantes, , France

Site Status RECRUITING

CHU de Nantes

Nantes, , France

Site Status RECRUITING

CHU de Nice

Nice, , France

Site Status RECRUITING

CHU de Nîmes

Nîmes, , France

Site Status RECRUITING

Hôpital St Antoine

Paris, , France

Site Status RECRUITING

Hôpital Cochin - APHP

Paris, , France

Site Status RECRUITING

Hôpital St Joseph

Paris, , France

Site Status RECRUITING

Hôpital Européen Georges Pompidou-APHP

Paris, , France

Site Status RECRUITING

CHU de Rennes

Rennes, , France

Site Status RECRUITING

CHU de Rouen

Rouen, , France

Site Status RECRUITING

Clinique Santé Atlantique

Saint-Herblain, , France

Site Status RECRUITING

CHU de Strasbourg

Strasbourg, , France

Site Status RECRUITING

CHU de Toulouse

Toulouse, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Jérémie Jacques, Pr

Role: CONTACT

05 55 05 87 72

Juge Sandra, Dr

Role: CONTACT

05 55 05 64 14

Facility Contacts

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Clara CY YZET, Dr

Role: primary

Edouard EC CHABRUN, Dr

Role: primary

Stéphane SK KOCH, Dr

Role: primary

Arthur AB BERGER, Dr

Role: primary

Lucille LQ QUENERHVE, Dr

Role: primary

Thibault TD DEGAND, Dr

Role: primary

Jérémie JJ Jacques, Pr

Role: primary

05 55 05 87 72

Mathieu MP PIOCHE, Pr

Role: primary

Vincent VL LEPILLIEZ, Dr

Role: primary

Sarah SL LEBALNC, Dr

Role: backup

Maxime MP PALAZZO, Dr

Role: primary

Antoine AB DEBOURDEAU, Dr

Role: primary

Jean-Baptiste JBC CHEVAUX, Dr

Role: primary

Bertrand BB BRIEAU, Dr

Role: primary

Emmanuel EC CORON, Pr

Role: primary

Geoffroy VANBIERVLIET GW Geoffroy VANBIERVLIET, Pr

Role: primary

Ludovic LC CAILLO, Dr

Role: primary

Xavier XD DRAY, Dr

Role: primary

Stanislas SC CHAUSSADE, Pr

Role: primary

Yann YLB LE-BALEUR, Dr

Role: primary

Gabriel GR RAHMI, Pr

Role: primary

Timothee TW WALLENHORST, Dr

Role: primary

Chloé CM MELCHIOR, Pr

Role: primary

Nicolas MUSQUER, Dr

Role: primary

Lucile LH HEROIN, Dr

Role: primary

Karl KB BARANGE, Dr

Role: primary

References

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Van der Voort V, Schaefer M, Wallenhorst T, Lepilliez V, Degand T, Le Baleur Y, Leclercq P, Berger A, Chabrun E, Brieau B, Barret M, Rahmi G, Legros R, Rivory J, Leblanc S, Vanbiervliet G, Alfarone L, Magne J, Zeevaert JB, Albouys J, Perrod G, Yzet C, Lepetit H, Belle A, Chaussade S, Rostain F, Dahan M, Lupu A, Chevaux JB, Pioche M, Jacques J; FECCo Group collaborators. Rectal versus colonic submucosal cancer rates and procedural outcomes in large non-pedunculated polyps: French ESD registry data. Gut. 2025 Oct 12:gutjnl-2024-332970. doi: 10.1136/gutjnl-2024-332970. Online ahead of print.

Reference Type DERIVED
PMID: 41083216 (View on PubMed)

Yzet C, Wallenhorst T, Jacques J, Figueiredo Ferreira M, Rivory J, Rostain F, Masgnaux LJ, Grimaldi J, Legros R, Lafeuille P, Albouys J, Subtil F, Schaefer M, Pioche M. Traction-assisted endoscopic submucosal dissection for resection of ileocecal valve neoplasia: a French retrospective multicenter case series. Endoscopy. 2024 Oct;56(10):790-796. doi: 10.1055/a-2316-4910. Epub 2024 Apr 29.

Reference Type DERIVED
PMID: 38684193 (View on PubMed)

Yzet C, Le Baleur Y, Albouys J, Jacques J, Doumbe-Mandengue P, Barret M, Abou Ali E, Schaefer M, Chevaux JB, Leblanc S, Lepillez V, Privat J, Degand T, Wallenhorst T, Rivory J, Chaput U, Berger A, Aziz K, Rahmi G, Coron E, Kull E, Caillo L, Vanbiervliet G, Koch S, Subtil F, Pioche M. Use of endoscopic submucosal dissection or full-thickness resection device to treat residual colorectal neoplasia after endoscopic resection: a multicenter historical cohort study. Endoscopy. 2023 Nov;55(11):1002-1009. doi: 10.1055/a-2116-9930. Epub 2023 Jul 27.

Reference Type DERIVED
PMID: 37500072 (View on PubMed)

Patenotte A, Yzet C, Wallenhorst T, Subtil F, Leblanc S, Schaefer M, Walter T, Lambin T, Fenouil T, Lafeuille P, Chevaux JB, Legros R, Rostain F, Rivory J, Jacques J, Lepilliez V, Pioche M. Diagnostic endoscopic submucosal dissection for colorectal lesions with suspected deep invasion. Endoscopy. 2023 Feb;55(2):192-197. doi: 10.1055/a-1866-8080. Epub 2022 Jun 1.

Reference Type DERIVED
PMID: 35649429 (View on PubMed)

Other Identifiers

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87RI20-0021_FECCo

Identifier Type: -

Identifier Source: org_study_id

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