Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
68 participants
INTERVENTIONAL
2017-05-30
2019-09-25
Brief Summary
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patients who are scheduled for CECT for HCC diagnosis or surveillance are eligible for this study and allocated to either standard protocol or double-low dose protocol using spectral CT with low radiation dose and low dose of contrast media, within clinically accpetable range.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
DIAGNOSTIC
TRIPLE
Study Groups
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Double Low-Dose protocol CT
Low radiation dose + low amount of iodine contrast media at spectral CT (Philips Healthcare)
Double Low-Dose protocol CT
Double low-dose protocol CT (Low radiation dose quadriphasic liver CT and low dose of iodine contrast media) at spectral dual energy CT scanner
Standard protocol CT
Standard protocol quadriphasic liver CT according to current liver CT protocol in our institution, at spectral CT (Philips Healthcare)
Standard protocol CT
standard protocol CT (standard dose quadriphasic liver CT and standard dose of iodine contrast media) at spectral dual energy CT scanner
Interventions
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Double Low-Dose protocol CT
Double low-dose protocol CT (Low radiation dose quadriphasic liver CT and low dose of iodine contrast media) at spectral dual energy CT scanner
Standard protocol CT
standard protocol CT (standard dose quadriphasic liver CT and standard dose of iodine contrast media) at spectral dual energy CT scanner
Eligibility Criteria
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Inclusion Criteria
* signed informed consent
* scheduled for contrast enhanced liver CT for HCC surveillance or diagnosis
Exclusion Criteria
* history of iodine hypersensitivity
* renal dysfunction (Estimated GFR \< 30mL/min/1.73m2) or on dialysis
* metformin medication within 48 hours
* any other contraindication of CE-CT
* BMI \> or = 30
20 Years
ALL
No
Sponsors
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Philips Healthcare
INDUSTRY
Seoul National University Hospital
OTHER
Responsible Party
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Jeong Min Lee
Professor
Principal Investigators
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Jeong Min Lee, MD
Role: PRINCIPAL_INVESTIGATOR
Seoul National University Hospital
Locations
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Seoul National University Hospital
Seoul, , South Korea
Countries
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References
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Yoon JH, Chang W, Lee ES, Lee SM, Lee JM. Double Low-Dose Dual-Energy Liver CT in Patients at High-Risk of HCC: A Prospective, Randomized, Single-Center Study. Invest Radiol. 2020 Jun;55(6):340-348. doi: 10.1097/RLI.0000000000000643.
Other Identifiers
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SNUH-2016-2830
Identifier Type: -
Identifier Source: org_study_id
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