Relationship Between Serotonin and Brain Response to Social Dominance and Emotion Perception.

NCT ID: NCT03041870

Last Updated: 2019-07-16

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 34 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-11-14
• Study Completion Date: 2019-06-21

Brief Summary

Previous studies have already revealed the involvement of the serotoninergic system in the social behavior process. For example, more serotonin (5HT) was found in dominant male adult monkeys. Little is known about the serotoninergic implication in human's social behavior. The project aims to clarify the role of the serotoninergic system in social behavior in relation to the process of social hierarchical information. In order to determine how serotoninergic system is involved, the investigator will use a new technic TEP-fMRI. This technic allows us to measure the brain activity and the serotoninergic transporter occupancy (using the [C11]-DASB) at the same time. The current study aims to investigate whether serotonin transporter (5-HTT) activity correlates with the neural response (BOLD) during the detection of social dominance in facial expressions or other measures of social information processing. Blood sample, SLC6A4 (allele coding for the 5HT transporter) genotyping and neuropsychological questionnaires will give at the investigator more information and allow to investigate whether performance on social information processing is modulated by personality trait and genotype.

Conditions

Healthy Volunteers

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Dominance

Healthy subjects

Group Type: EXPERIMENTAL

PET-fMRI scan

Intervention Type: DEVICE

fMRI scan include MR sequences: BOLD and fMRI. The PET acquisition will be carried out in dynamic for 90 consecutive minutes following intravenous administration of 4 MBq / kg dose of \[11C\]DASB bolus.

Interventions

PET-fMRI scan

fMRI scan include MR sequences: BOLD and fMRI. The PET acquisition will be carried out in dynamic for 90 consecutive minutes following intravenous administration of 4 MBq / kg dose of \[11C\]DASB bolus.

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• French speaking
• Normal vision
• Age from 18 to 45
• Without psychiatric antecedent
• Without any neurologic antecedent
• Not taking psychotropic or anxiolytic drugs
• Having health insurance coverage

Exclusion Criteria

• The subject does not wish to be notified of any anomalies detected during MRI
• Subjects suffering from claustrophobia
• Subjects carrying magnetic metal objects that cannot be removed as cochlear implant, surgical clips, piercings, pacemakers, mechanical valves
• Subjects participating in a clinical trial or being in a period of exclusion from a previous clinical trial
• Person under guardianship or curatorship or deprived of liberty or in emergencies
• Taking unauthorized treatment in the month before the completion of the review
• Person whose physical or mental condition does not allow him to pass the test study

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Hospices Civils de Lyon

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Christian SCHEIBER

Role: PRINCIPAL_INVESTIGATOR

Hospices Civils de Lyon - CNRS UMR 5229

Locations

Hospices Civils de Lyon

Bron, , France

Countries

France

Other Identifiers

2016-A01588-43

Identifier Type: OTHER

Identifier Source: secondary_id

69HCL16_0014

Identifier Type: -

Identifier Source: org_study_id