Effect of Preoperative Clindamycin on Postoperative Endodontic Pain
NCT ID: NCT03033472
Last Updated: 2017-01-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
UNKNOWN
PHASE2/PHASE3
72 participants
INTERVENTIONAL
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Effect of Preoperative Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain
NCT03033147
Effect of Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain
NCT03007342
Pretreatment Aceclofenac Effect on Pain and Analgesic Intake After Endodontic Treatment
NCT03335007
Effect of Occlusal Reduction on Post-operative Pain
NCT03189771
Effect of Irrigation With Antibiotic-containing Solutions on Postoperative Pain and Intra-canal Bacteria
NCT04035070
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Clinical diagnosis of symptomatic apical periodontitis is to be confirmed.
Before root canal treatment, eligible participants will be randomly assigned to one of the following groups: experimental group (taking 600 mg of clindamycin orally) or control group (taking placebo ) 30 minutes before the start of the treatment. Single-visit root canal treatment will be performed.
Each patient will receive a 7-day diary to record postoperative pain and swelling.In case of pain, the participant will be instructed to take an analgesic. Post-operative pain will be measured as a primary outcome on 11-point scale (NRS) at the following time points: 6, 12, 24, 48, 72 hours and 7 days. The occurrence of swelling will be reported by participant as a secondary outcome
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Clindamycin
600 mg of Clindamycin orally 30 minutes before root canal treatment
600 mg Clindamycin orally
600 mg Clindamycin orally 30 minutes before treatment
Placebo
placebo 30 minutes Orally before treatment
Oral Placebo
Oral Placebo 30 minutes before treatment
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
600 mg Clindamycin orally
600 mg Clindamycin orally 30 minutes before treatment
Oral Placebo
Oral Placebo 30 minutes before treatment
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
2. Mandibular posterior teeth.
3. Patients in good health.
4. Patients who can understand pain scales (NRS).
5. Patients able to sign informed consent.
Exclusion Criteria
2. Retreatment cases
3. Patients with weeping canals.
18 Years
60 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Cairo University
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Nermeen Saeed Abdel Ghany El Sedawy
principal Investigator
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Nermeen SA El Sedawy, Post Graduate
Role: PRINCIPAL_INVESTIGATOR
Cairo University
Suzan AW Wanees, PhD
Role: STUDY_CHAIR
Cairo Univertsity
Shaimaa Gawdat, PhD
Role: STUDY_DIRECTOR
Cairo University
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
References
Explore related publications, articles, or registry entries linked to this study.
Cope A, Francis N, Wood F, Mann MK, Chestnutt IG. Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults. Cochrane Database Syst Rev. 2014 Jun 26;(6):CD010136. doi: 10.1002/14651858.CD010136.pub2.
Lindeboom JA, Frenken JW, Valkenburg P, van den Akker HP. The role of preoperative prophylactic antibiotic administration in periapical endodontic surgery: a randomized, prospective double-blind placebo-controlled study. Int Endod J. 2005 Dec;38(12):877-81. doi: 10.1111/j.1365-2591.2005.01030.x.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
CEBC-CU-2017-01-09
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.