Ultrasound-Based Imaging Using the Aixplorer System in Diagnosing Prostate Cancer in Patients Undergoing Biopsy

NCT ID: NCT03013413

Last Updated: 2025-05-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

99 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-09-30

Study Completion Date

2014-05-31

Brief Summary

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This clinical trial studies an ultrasound-based imaging procedure called elastography using the Aixplorer system in diagnosing prostate cancer in patients undergoing biopsy. Ultrasound is a non-invasive imaging technique that uses high-frequency sound waves to produce images of internal structures. Elastography uses ultrasound imaging techniques to examine the stiffness or elasticity of a tissue and may enhance the detection of prostate cancer. It is not yet known whether elastography imaging using the Aixplorer system works better than standard ultrasound imaging in detecting prostate cancer.

Detailed Description

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PRIMARY OBJECTIVES:

I. To evaluate the detection of prostate cancer with elastography using the Aixplorer scanner.

SECONDARY OBJECTIVES:

I. To obtain quantitative data on the elastic properties of normal and malignant tissue in the prostate of patients referred for ultrasound guided biopsy.

II. To compare the Gleason grade of prostate cancers detected with elastography to the Gleason grade of tumors detected by conventional systematic biopsy.

Conditions

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Prostate Carcinoma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Diagnostic (elastography imaging using the Aixplorer system)

Patients undergo ultrasound-based elastography imaging using the Aixplorer system followed by standard of care ultrasound-guided prostate biopsy over approximately 25 minutes.

Group Type EXPERIMENTAL

Shear Wave Elastography

Intervention Type PROCEDURE

Undergo ultrasound-based elastography imaging using the Aixplorer system

Ultrasound Elasticity Imaging

Intervention Type PROCEDURE

Undergo ultrasound-based elastography imaging using the Aixplorer system

Ultrasound-Guided Prostate Biopsy

Intervention Type PROCEDURE

Undergo standard of care ultrasound-guided prostate biopsy

Interventions

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Shear Wave Elastography

Undergo ultrasound-based elastography imaging using the Aixplorer system

Intervention Type PROCEDURE

Ultrasound Elasticity Imaging

Undergo ultrasound-based elastography imaging using the Aixplorer system

Intervention Type PROCEDURE

Ultrasound-Guided Prostate Biopsy

Undergo standard of care ultrasound-guided prostate biopsy

Intervention Type PROCEDURE

Other Intervention Names

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Transient Elastography

Eligibility Criteria

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Inclusion Criteria

* Be scheduled for a clinically indicated biopsy of the prostate
* Agree to an ultrasound examination using the Aixplorer system
* Sign an institutional review board (IRB) approved informed consent prior to any study procedures

Exclusion Criteria

• Recent prostate biopsy within 90 days
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Sidney Kimmel Cancer Center at Thomas Jefferson University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ethan Halpern, MD

Role: PRINCIPAL_INVESTIGATOR

Thomas Jefferson University

Locations

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Thomas Jefferson University

Philadelphia, Pennsylvania, United States

Site Status

Countries

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United States

Related Links

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http://www.kimmelcancercenter.org

Sidney Kimmel Cancer Center

http://hospitals.jefferson.edu/

Thomas Jefferson University Hospital

Other Identifiers

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JT 1614

Identifier Type: OTHER

Identifier Source: secondary_id

11D.349

Identifier Type: -

Identifier Source: org_study_id

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