Feasibility Study of Ultrasound Elastography Detecting Prostate Cancer

NCT ID: NCT03077126

Last Updated: 2017-03-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-04-11

Study Completion Date

2015-09-18

Brief Summary

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The main purpose of this study is to determine the accuracy and feasibility (possibility) of Aixplorer® ShearWave Elastography (SWE™) Ultrasound System (made by SuperSonic Imagine, Inc.) for detecting prostate cancer in men undergoing radical prostatectomy.

Detailed Description

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The point estimate and its 95% confidence interval will be calculated using the exact binominal method. Identification of suspicious cancer tissue in a 12 prostate zone schema: Participants will undergo USE: Aixplorer® ShearWave Elastography (SWE™), (SuperSonic Imagine). Areas of the prostate with high suspicion for harboring cancer will be recorded in a 12 zone prostate schema. For study purposes the prostate will be divided into Zone 1(Left Lateral Base), Zone 2 (Left Base), Zone 3 (Right Base), Zone 4 (Right Lateral Base), Zone 5 (Left Lateral Mid), Zone 6 (Left Mid), Zone 7 (Right Mide), Zone 8 (Right Lateral Mid), Zone 9 (Left Lateral Apex), Zone 10 (Left Apex), Zone 11 (Right Apex), Zone 12 (Right Lateral Apex).

Conditions

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Prostate Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Pre-surgery Ultrasound

Aixplorer® ShearWave Elastography (SWE™) Ultrasound. Participants will undergo ultrasound prep with Fleet Enema and ultrasound procedure at their pre-op visit one to two weeks before their standard of care prostatectomy.

Group Type OTHER

Fleet Enema

Intervention Type OTHER

Since a probe will be introduced into the participant's rectal area, participants will be instructed to give themself one regular Fleet enema.

Aixplorer® ShearWave Elastography (SWE™)

Intervention Type DEVICE

Pre-surgery ultrasound: Aixplorer® ShearWave Elastography (SWE™) Ultrasound System (made by SuperSonic Imagine, Inc.). The device is used transrectally. This device (ultrasound system) has been cleared by the United States Food and Drug Administration (FDA) for the indication for use as described in this consent form.

Pre-surgery Ultrasound

Intervention Type DIAGNOSTIC_TEST

The ultrasound procedure referenced above will be performed at the participant's pre-op visit one to two weeks before their surgery.

Prostatectomy

Intervention Type PROCEDURE

Participants will undergo radical prostatectomy as currently performed at our Moffitt Cancer Center. This procedure is performed under general anesthesia in the operating room. This is considered standard of care.

Interventions

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Fleet Enema

Since a probe will be introduced into the participant's rectal area, participants will be instructed to give themself one regular Fleet enema.

Intervention Type OTHER

Aixplorer® ShearWave Elastography (SWE™)

Pre-surgery ultrasound: Aixplorer® ShearWave Elastography (SWE™) Ultrasound System (made by SuperSonic Imagine, Inc.). The device is used transrectally. This device (ultrasound system) has been cleared by the United States Food and Drug Administration (FDA) for the indication for use as described in this consent form.

Intervention Type DEVICE

Pre-surgery Ultrasound

The ultrasound procedure referenced above will be performed at the participant's pre-op visit one to two weeks before their surgery.

Intervention Type DIAGNOSTIC_TEST

Prostatectomy

Participants will undergo radical prostatectomy as currently performed at our Moffitt Cancer Center. This procedure is performed under general anesthesia in the operating room. This is considered standard of care.

Intervention Type PROCEDURE

Other Intervention Names

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enema ultrasound device probe Aixplorer® ShearWave Elastography (SWE™) ultrasound elastography prostate surgery

Eligibility Criteria

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Inclusion Criteria

* Men with prostate cancer who elect surgery as the primary treatment of their cancer and to be performed at the Moffitt Cancer Center.
* Biopsy confirmed prostate cancer with at least ten biopsies performed for diagnosis.
* Location of cancer specified in the pathology report.
* Pathology reviewed by Moffitt pathologist

Exclusion Criteria

* Less than ten biopsies obtained at time of diagnosis.
* Location of cancer not specified.
* Pathology not reviewed by Moffitt pathologist.
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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H. Lee Moffitt Cancer Center and Research Institute

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Julio Pow-Sang, M.D.

Role: PRINCIPAL_INVESTIGATOR

H. Lee Moffitt Cancer Center and Research Institute

Locations

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H. Lee Moffitt Cancer Center and Research Institute

Tampa, Florida, United States

Site Status

Countries

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United States

Other Identifiers

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MCC-17294

Identifier Type: -

Identifier Source: org_study_id

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