Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
150 participants
OBSERVATIONAL
2016-11-01
2017-07-30
Brief Summary
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Detailed Description
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The investigators aim to isolate and cryopreserve peripheral blood mononuclear cells (PBMCs) from whole blood to perform functional assays on mitochondrial respiratory capacity and ROS. Furthermore, the investigators will investigate the association between biomarkers and frailty, quality of life, functional performance, fatigue and risk of depression.
The investigators hypothesize that this profiling approach will allow the evaluation of the progression of age-dependent sarcopenia and uncover novel therapeutic targets.
Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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Group 1
Geriatric patient with Sarcopenia
No interventions assigned to this group
Group 2
Geriatric Patient without Sarcopenia
No interventions assigned to this group
Group 3
healthy control group
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Informed written consent
* Normal cognitive status according to Mini-Mental State Examination (MMSE ≥ 24 points)
* Life expectancy of \> 3 months according to treating doctor
* without implanted Defibrillation
* without acute Sepsis
* without neurodegenerative diseases, especially amyotrophic lateral sclerosis (ALS) and Huntington
Exclusion Criteria
* Lack of informed written consent
* Low cognitive status according to Mini-Mental State Examination (MMSE \< 24 points)
* Life expectancy of \< 3 months according to treating doctor
* Implanted Defibrillation
* Acute Sepsis
* neurodegenerative diseases, especially amyotrophic lateral sclerosis (ALS) and Huntington
60 Years
85 Years
ALL
Yes
Sponsors
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German Institute of Human Nutrition
OTHER
Charite University, Berlin, Germany
OTHER
Responsible Party
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Kristina Norman
PD Dr.
Principal Investigators
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Kristina Norman, PD Dr.
Role: PRINCIPAL_INVESTIGATOR
Charite Research Group on Geriatrics
Locations
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Charite University Medicine, Research Group on Geriatrics
Berlin, , Germany
Countries
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References
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Marzetti E, Calvani R, Cesari M, Buford TW, Lorenzi M, Behnke BJ, Leeuwenburgh C. Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials. Int J Biochem Cell Biol. 2013 Oct;45(10):2288-301. doi: 10.1016/j.biocel.2013.06.024. Epub 2013 Jul 8.
Leger B, Derave W, De Bock K, Hespel P, Russell AP. Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation. Rejuvenation Res. 2008 Feb;11(1):163-175B. doi: 10.1089/rej.2007.0588.
Other Identifiers
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EA1/260/16
Identifier Type: -
Identifier Source: org_study_id
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