Feasibility of Estimating the Prevalence of Malnutrition, Frailty and Sarcopenia in Older People in UK Biobank, Cross-sectional Study: A Study Protocol
NCT ID: NCT04655456
Last Updated: 2021-04-30
Study Results
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Basic Information
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COMPLETED
381000 participants
OBSERVATIONAL
2007-04-01
2020-11-20
Brief Summary
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Methods/design: This is a cross-sectional study design that will use the UK Biobank database, which includes 381,000 participants males and females, aged 50 years and above, who completed the UK Biobank baseline assessments were included that is a subset from the main sample size from the UK Biobank. For baseline, details of participant's characteristics will be included. All three conditions will be identified as malnutrition by using GLIM criteria, while frailty by using two models; the first model will be the 36 deficits model and phenotype model. Finally, sarcopenia condition will be judge according to EWGSOP standard. All these models will be determining the feasibility to apply it using the available database in the UK Biobank.
Discussion: This proposed study will help in understanding the relation between malnutrition, frailty and sarcopenia. As in worldwide, there is little published research on the overlap between malnutrition, frailty and sarcopenia. Despite definitions and diagnostic criteria were developed for these conditions. There is conflict extend to the definitions and identification criteria's. This study will use UK Biobank database to measuring the estimate prevalence in older people and determine the overlap between three conditions.
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Detailed Description
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There are four phases of assessment in UK Biobank. The first phase was the UK Biobank Pilot assessment that included 3798 participants from Stockport only in 2006. Then, the second phase was the initial assessment visit that started in 2007 until 2010. This was the baseline assessment and included approximately 500000 participants. After that, the third phase was conducted and called the first repeat assessment visit which took place between 2012-2013 and included 20346 participants. Lastly, the imaging visit which is considered the fourth phase started in 2014 until present.
Conditions
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Study Design
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OTHER
CROSS_SECTIONAL
Eligibility Criteria
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Exclusion Criteria
50 Years
ALL
Yes
Sponsors
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University of Manchester
OTHER
Responsible Party
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Nada Adnan AlMohaisen
PhD Student
Principal Investigators
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Sorrel Burden
Role: STUDY_DIRECTOR
University of Manchester
Locations
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Nada Almohaisen
Manchester, , United Kingdom
Countries
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References
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AlMohaisen N, Gittins M, Todd C, Burden S. What is the overlap between malnutrition, frailty and sarcopenia in the older population? Study protocol for cross-sectional study using UK Biobank. PLoS One. 2022 Dec 6;17(12):e0278371. doi: 10.1371/journal.pone.0278371. eCollection 2022.
Related Links
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Hereditary Hemochromatosis Associations with Frailty, SarcopThis is the title of a study used UK Biobank for two conditions frailty and sarcopenia. We are aiming to have similar method in measuring the conditions
This study used UK Biobank in measuring the frailty condition for different age groups. We aimed using similar method in measuring frailty
This study point out the overlap and evidence gaps in the diagnosis and treatment of frailty and malnutrition.
This is evidence that shows differences between two models in measuring frailty. As this study has one object in comparing the results from both models.
In this study we used the definition of sarcopenia and criteria of diagnosed in measuring the prevalence.
This study we used their definition of malnutrition and criteria of diagnosed.
Other Identifiers
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Manchester1
Identifier Type: -
Identifier Source: org_study_id
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