Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
43 participants
INTERVENTIONAL
2018-01-15
2020-10-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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exercise and protein supplementation
Predominately resistance exercise training 2-3x week for 18 months; 1.5-1.7 g/kg/d total protein supplementation, Calcium and Vitamin-D-supplementation (i.e. 800 mg/800 IE/d)
exercise
3x week predominately resistance exercise for 18 months
control
Calcium and Vitamin-D-supplementation (i.e. 800 mg/800 IE/d)
No interventions assigned to this group
Interventions
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exercise
3x week predominately resistance exercise for 18 months
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Osteopenia at the lumbar spine or hip according to WHO (\> -1 SD T-Score)
* community dwelling people
* able to transfer to our lab
Exclusion Criteria
* history of hip fracture
* medication/diseases that relevantly affect muscle/bone metabolism (last 2 years)
* alcohol abuses of more than 60 g/d ethanol
* cardio-vascular diseases that prevent exercise
* very low physical capacity that prevent exercise in a group setting
SD: Standard Deviation
70 Years
MALE
Yes
Sponsors
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University of Erlangen-Nürnberg Medical School
OTHER
Responsible Party
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Principal Investigators
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Klaus Engelke, PhD
Role: STUDY_CHAIR
Institute of Medical Physics, University of Erlangen-Nürnberg, Germany
Locations
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Institute of Medical Physics, University of Erlangen-Nürnberg, Germany
Erlangen, , Germany
Countries
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References
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Kemmler W, Bebenek M, Kohl M, von Stengel S. Exercise and fractures in postmenopausal women. Final results of the controlled Erlangen Fitness and Osteoporosis Prevention Study (EFOPS). Osteoporos Int. 2015 Oct;26(10):2491-9. doi: 10.1007/s00198-015-3165-3. Epub 2015 May 12.
Kemmler W, von Stengel S. Bone: High-intensity exercise to prevent fractures - risk or gain? Nat Rev Endocrinol. 2018 Jan;14(1):6-8. doi: 10.1038/nrendo.2017.148. Epub 2017 Nov 10. No abstract available.
Kemmler W, von Stengel S, Kohl M. Exercise frequency and bone mineral density development in exercising postmenopausal osteopenic women. Is there a critical dose of exercise for affecting bone? Results of the Erlangen Fitness and Osteoporosis Prevention Study. Bone. 2016 Aug;89:1-6. doi: 10.1016/j.bone.2016.04.019. Epub 2016 Apr 21.
Kircher K, Chaudry O, Nagel AM, Ghasemikaram M, Uder M, Jakob F, Kohl M, Kemmler W, Engelke K. Effects of high-intensity training on fatty infiltration in paraspinal muscles in elderly males with osteosarcopenia - the randomized controlled FrOST study. BMC Geriatr. 2024 Feb 8;24(1):141. doi: 10.1186/s12877-024-04736-5.
Kemmler W, Kohl M, von Stengel S, Schoene D. Effect of high-intensity resistance exercise on cardiometabolic health in older men with osteosarcopenia: the randomised controlled Franconian Osteopenia and Sarcopenia Trial (FrOST). BMJ Open Sport Exerc Med. 2020 Dec 24;6(1):e000846. doi: 10.1136/bmjsem-2020-000846. eCollection 2020.
Kemmler W, Kohl M, Frohlich M, Schoene D, von Stengel S. Detraining effects after 18 months of high intensity resistance training on osteosarcopenia in older men-Six-month follow-up of the randomized controlled Franconian Osteopenia and Sarcopenia Trial (FrOST). Bone. 2021 Jan;142:115772. doi: 10.1016/j.bone.2020.115772. Epub 2020 Nov 26.
Other Identifiers
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FROST
Identifier Type: -
Identifier Source: org_study_id