Evaluation of Leg Muscular Activity Using MRI and 11C-acetate PET/MRI. Pilot Study
NCT ID: NCT02969603
Last Updated: 2016-11-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE1/PHASE2
10 participants
INTERVENTIONAL
2013-09-30
2016-12-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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Healthy volunteers- MRI
MRI scan for morphological assessment of muscle structures and anatomy
Magnetic Resonance Imaging
Magnetic Resonance Imaging as reference
Healthy Volunteers- PET/MRI
The volunteers will undergo a combined \[11C\]acetate PET/MRI scan
Magnetic Resonance combined with Positron Emission Tomography
Comparison with MRI only, to assess muscular activity, creation of anatomic images of muscle activity and resolution of metabolic activity distribution within exercising skeletal muscle
Interventions
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Magnetic Resonance Imaging
Magnetic Resonance Imaging as reference
Magnetic Resonance combined with Positron Emission Tomography
Comparison with MRI only, to assess muscular activity, creation of anatomic images of muscle activity and resolution of metabolic activity distribution within exercising skeletal muscle
Eligibility Criteria
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Inclusion Criteria
* Acceptance of the research protocol: signature of the informed consent form after oral and written information about the protocol through the patient information document.
* Volunteers that could undergo 1h15 to 1h30 immobilization (MRI exam duration in time).
* Male volunteer aged in the range 18 to 35 years.
* Acceptance of the research protocol: signature of the informed consent form after oral and written information about the protocol through the patient information document.
* Volunteers that could undergo 1.5 to 2.0 hours immobilization (PET/MRI exam duration in time).
* Volunteers should practice regular physical activity, defined as 50 min per day (in a single session), 2 days per week of physical activity as a minimum (no maximum is fixed).
Exclusion Criteria
* Co morbidities impeding on the protocol comprehension or fulfilment.
* Illnesses that do not allow to lay down on an examination table.
* Pacemaker holder.
* Metal implants that would preclude MRI imaging
* Claustrophobia: Subjects will be questioned about possible discomfort with being in an enclosed space (e.g., MRI scanner). Those who report such problems will be excluded.
* Medical radiation exposure within the last five years (normal population should not be exposed to medical radiation higher or equal to 1 mSv per year).
* Pre-existing neurological or muscular lesions on the legs.
* Co morbidities impeding on the protocol comprehension or fulfilment.
* Illnesses that do not allow to lay down on an examination table.
* Pacemaker holder.
* Metal implants that would preclude MRI imaging
* Claustrophobia: Subjects will be questioned about possible discomfort with being in an enclosed space (e.g., MRI scanner). Those who report such problems will be excluded.
18 Years
35 Years
MALE
Yes
Sponsors
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Osman Ratib
OTHER
Responsible Party
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Osman Ratib
Dr.
Principal Investigators
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Osman Ratib, Pr.
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Geneva
Locations
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Service de Medecine Nucléaire et Imagerie moléculaire- HUG
Geneva, , Switzerland
Countries
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Other Identifiers
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2013DR2115
Identifier Type: -
Identifier Source: org_study_id