VCRC Tissue Repository

NCT ID: NCT02967068

Last Updated: 2026-01-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-11-30

Study Completion Date

2028-12-31

Brief Summary

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The purpose of this study is to collect existing tissue specimens from subjects enrolled in Vasculitis Clinical Research Consortium (VCRC) studies. Analysis of these tissue specimens and linked clinical data collected through VCRC studies may lead to the identification and development of a series of translational research projects. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.

Detailed Description

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Biopsy specimens collected as standard of care for these diseases will be retrieved and used in research. The most common biopsies performed are kidney, lung, skin, nerves, and vessels; however, other tissue is also of interest for the study. Biopsies are not performed as part of this protocol, rather we will request consent to collect biopsy specimens already collected under routine care.

Conditions

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Aortitis Cutaneous Vasculitis Eosinophilic Granulomatosis With Polyangiitis Giant Cell Arteritis Granulomatosis With Polyangiitis (Wegener's) Henoch-Schonlein Purpura IgA Vasculitis Microscopic Polyangiitis Polyarteritis Nodosa Takayasu Arteritis Churg-Strauss Syndrome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* A participant will be deemed eligible for this study if the participant is/was enrolled in another one of the VCRC observational/longitudinal protocols (5502, 5503, 5504, 5505, 5506, 5507, 5563) and/or one of the VCRC interventional studies (5522, 5523, 5526, 5527, or 5562).

Exclusion Criteria

* Inability to give informed consent (or their guardians in the case of children) and to sign the consent form.
* Unwilling to allow the use of their tissue for research.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NIH

Sponsor Role collaborator

National Center for Advancing Translational Sciences (NCATS)

NIH

Sponsor Role collaborator

Office of Rare Diseases (ORD)

NIH

Sponsor Role collaborator

University of Pennsylvania

OTHER

Sponsor Role lead

Responsible Party

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Peter Merkel

Chief, Division of Rheumatology Professor of Medicine and Epidemiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Peter A Merkel, MD, MPH

Role: STUDY_CHAIR

University of Pennsylvania

Locations

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Brigham and Women's Hospital

Boston, Massachusetts, United States

Site Status COMPLETED

Boston University School of Medicine

Boston, Massachusetts, United States

Site Status COMPLETED

Cleveland Clinic

Cleveland, Ohio, United States

Site Status COMPLETED

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

Site Status COMPLETED

University of Utah

Salt Lake City, Utah, United States

Site Status COMPLETED

St. Joseph's Healthcare

Hamilton, Ontario, Canada

Site Status RECRUITING

University of Toronto Mount Sinai Hospital

Toronto, Ontario, Canada

Site Status RECRUITING

Countries

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United States Canada

Central Contacts

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Katie Doyle

Role: CONTACT

Facility Contacts

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Katie Doyle

Role: primary

Sandra Messier

Role: primary

Nazrana Haq

Role: primary

Related Links

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http://rarediseasesnetwork.org/vcrc/

Vasculitis Clinical Research Consortium

http://rarediseasesnetwork.org

Rare Diseases Clinical Research Network

Other Identifiers

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U54AR057319

Identifier Type: NIH

Identifier Source: secondary_id

View Link

VCRC5511

Identifier Type: -

Identifier Source: org_study_id

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