Postprandial Blood Glucose and Insulin Levels Following Consumption of Lentil-containing Food Products

NCT ID: NCT02923089

Last Updated: 2018-04-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-31

Study Completion Date

2018-03-31

Brief Summary

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This study will recruit 20 healthy adults (male and female) to complete 9 study visits where they will consume different food products (chili, soup and muffin) with or without lentils incorporated into the them. Blood samples will be obtained by finger prick before and for 2 hours after the meal and analyzed for glucose and insulin.

Detailed Description

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The purpose of the current study is to determine the effects of lentil-containing food products on postprandial blood glucose and insulin levels in healthy premenopausal women and men aged 18-40 years old.This study will use a randomized crossover design. Participants will complete a series of 9 study visits during which participants will consume 9 study treatment meals consisting of muffins, soup and chilli, with and without lentils. Participants will then have their blood sampled for the following 2 hours by finger prick. Participants will remain seated during the test period. All study visits will occur at the Human Nutraceutical Research Unit and be separated by a washout period of 3-7 days. Throughout the study, it will be asked that participants' lifestyle and physical activity remain unchanged. Participants will be instructed to not start any new dietary approaches, and to not start any new natural health products (unless instructed by a physician).

Conditions

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Postprandial Glycemia in Healthy Adults

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Small Green Lentil Muffin

Muffin: 25g available carbohydrate from small green lentil

Group Type EXPERIMENTAL

Muffin: 25g available carbohydrate from small green lentil

Intervention Type OTHER

Comparison of postprandial blood glucose and insulin following consumption of food products with and without lentils.

Split Red Lentil Muffin

Muffin: 25g available carbohydrate from split red lentil

Group Type EXPERIMENTAL

Muffin: 25g available carbohydrate from split red lentil

Intervention Type OTHER

Comparison of postprandial blood glucose and insulin following consumption of food products with and without lentils.

Wheat Muffin

Muffin: 25g available carbohydrate from wheat

Group Type PLACEBO_COMPARATOR

Wheat muffin

Intervention Type OTHER

Comparison of postprandial blood glucose and insulin following consumption of food products with and without lentils.

Small Green Lentil Soup

Soup: 25g available carbohydrate from small green lentil

Group Type EXPERIMENTAL

Soup: 25g available carbohydrate from small green lentil

Intervention Type OTHER

Comparison of postprandial blood glucose and insulin following consumption of food products with and without lentils.

Split Red Lentil Soup

Soup: 25g available carbohydrate from split red lentil

Group Type EXPERIMENTAL

Soup: 25g available carbohydrate from split red lentil

Intervention Type OTHER

Comparison of postprandial blood glucose and insulin following consumption of food products with and without lentils.

Potato Soup

Soup: 25g available carbohydrate from potato

Group Type PLACEBO_COMPARATOR

Potato soup

Intervention Type OTHER

Comparison of postprandial blood glucose and insulin following consumption of food products with and without lentils.

Small Green Lentil Chili

Chili: 25g available carbohydrate from small green lentil

Group Type EXPERIMENTAL

Chili: 25g available carbohydrate from small green lentil

Intervention Type OTHER

Comparison of postprandial blood glucose and insulin following consumption of food products with and without lentils.

Split Red Lentil Chili

Chili: 25g available carbohydrate from split red lentil

Group Type EXPERIMENTAL

Chili: 25g available carbohydrate from split red lentil

Intervention Type OTHER

Comparison of postprandial blood glucose and insulin following consumption of food products with and without lentils.

Rice Chili

Chili: 25g available carbohydrate from rice

Group Type PLACEBO_COMPARATOR

Rice chili

Intervention Type OTHER

Comparison of postprandial blood glucose and insulin following consumption of food products with and without lentils.

Interventions

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Muffin: 25g available carbohydrate from small green lentil

Comparison of postprandial blood glucose and insulin following consumption of food products with and without lentils.

Intervention Type OTHER

Muffin: 25g available carbohydrate from split red lentil

Comparison of postprandial blood glucose and insulin following consumption of food products with and without lentils.

Intervention Type OTHER

Wheat muffin

Comparison of postprandial blood glucose and insulin following consumption of food products with and without lentils.

Intervention Type OTHER

Soup: 25g available carbohydrate from small green lentil

Comparison of postprandial blood glucose and insulin following consumption of food products with and without lentils.

Intervention Type OTHER

Soup: 25g available carbohydrate from split red lentil

Comparison of postprandial blood glucose and insulin following consumption of food products with and without lentils.

Intervention Type OTHER

Potato soup

Comparison of postprandial blood glucose and insulin following consumption of food products with and without lentils.

Intervention Type OTHER

Chili: 25g available carbohydrate from small green lentil

Comparison of postprandial blood glucose and insulin following consumption of food products with and without lentils.

Intervention Type OTHER

Chili: 25g available carbohydrate from split red lentil

Comparison of postprandial blood glucose and insulin following consumption of food products with and without lentils.

Intervention Type OTHER

Rice chili

Comparison of postprandial blood glucose and insulin following consumption of food products with and without lentils.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy men and women
* Age 18-40 years (aiming for equal distribution among 18-29, 30-40 years of age)
* BMI 20-30 kg/m2

Exclusion Criteria

* Diabetes (fasting blood glucose ≥7.0 mmol/L and/or 2hr blood glucose \>11.1 mmol/L post-75g OGTT) 1
* Impaired Glucose Tolerance (IGT) (Fasting blood glucose 6.1-6.9 mmol/L and/or 2hr blood glucose 7.8-11.0 mmol/L post-75g OGTT) 1
* Blood pressure \>140/90 mm Hg
* Any major medical condition including a history of AIDS or hepatitis
* Medical or surgical event requiring hospitalization within 3 months of randomization
* Any medications except a stable dose (3 months) of oral contraceptives, blood pressure or statin medications
* Natural health products (NHPs) used for glycemic control (all other NHPs okay as long as table for 3 months)
* Tobacco use
* Probiotic supplement use
* Dietary fibre supplement use
* Pulse consumption \>4 servings per week
* Food allergy or non-food life threatening allergy
* Alcohol consumption \>14 drinks/week or \>4 drinks/sitting
* Recent or intended significant weight loss or gain (\>4 kg in previous 3 months)
* Elite athletes
* Shift workers
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Agriculture and Agri-Food Canada

OTHER_GOV

Sponsor Role collaborator

University of Guelph

OTHER

Sponsor Role lead

Responsible Party

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Alison Duncan

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Alison M Duncan, PhD, RD

Role: PRINCIPAL_INVESTIGATOR

University of Guelph

Locations

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Human Nutraceutical Research Unit

Guelph, Ontario, Canada

Site Status

Countries

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Canada

Other Identifiers

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16AU008

Identifier Type: -

Identifier Source: org_study_id

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