Parental Consanguinity and Family History of Kidney Disease in Turkish Kidney Disease Population

NCT ID: NCT02917070

Last Updated: 2016-09-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2576 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-02-29

Study Completion Date

2016-08-31

Brief Summary

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Inbreeding and consanguineous marriages are known to increase the risk of autosomal recessive disorders. The aim of this study was to examine the association between consanguinity and kidney diseases in the adult Turkish population.

Detailed Description

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This was a national, cross-sectional study recruiting patients from nephrology out-patient clinics and dialysis units. All patients between 18 and 70 years of age who were on follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty from October 2009 to October 2015 were included in the study. All patients and healthy controls enrolled in this study gave informed consent to participate in the survey. They were all asked to answer a questionnaire including socio-demographic data, history of familial kidney disease and consanguineous marriage. Additional information was obtained from their private physicians and medical files. To ensure reliability of administration of the questionnaire, all interviewers underwent training using a standardized protocol.

Conditions

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Hereditary Diseases

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Patients

Patients who have chronic kidney diseases

Patients

Intervention Type OTHER

In this study we aimed to investigate effect of family history and consanguineous marriage in the development of CKD in the adult Turkish population.

Healthy controls

Healthy subjects

No interventions assigned to this group

Interventions

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Patients

In this study we aimed to investigate effect of family history and consanguineous marriage in the development of CKD in the adult Turkish population.

Intervention Type OTHER

Other Intervention Names

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Inbreeding marriage

Eligibility Criteria

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Inclusion Criteria

* follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty
* between 18-70 years old
* provide informed consent

Exclusion Criteria

* follow-up shorter than 6 months
* patients whose data were not available
* patients who were unwilling or unable to provide informed consent
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Istanbul University

OTHER

Sponsor Role lead

Responsible Party

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Yasar Caliskan

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Yasar Caliskan, Dr.

Role: PRINCIPAL_INVESTIGATOR

Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Nephrology

Locations

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Istanbul University, Istanbul Faculty of Medicine

Istanbul, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002 Feb;39(2 Suppl 1):S1-266. No abstract available.

Reference Type RESULT
PMID: 11904577 (View on PubMed)

Chronic Kidney Disease Prognosis Consortium; Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, Coresh J, Gansevoort RT. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet. 2010 Jun 12;375(9731):2073-81. doi: 10.1016/S0140-6736(10)60674-5. Epub 2010 May 17.

Reference Type RESULT
PMID: 20483451 (View on PubMed)

Suleymanlar G, Utas C, Arinsoy T, Ates K, Altun B, Altiparmak MR, Ecder T, Yilmaz ME, Camsari T, Basci A, Odabas AR, Serdengecti K. A population-based survey of Chronic REnal Disease In Turkey--the CREDIT study. Nephrol Dial Transplant. 2011 Jun;26(6):1862-71. doi: 10.1093/ndt/gfq656. Epub 2010 Nov 4.

Reference Type RESULT
PMID: 21051501 (View on PubMed)

Gumprecht J, Zychma MJ, Grzeszczak W, Zukowska-Szczechowska E; End-stage Renal Disease Study Group. Human SA gene Pst1 polymorphism and chronic renal failure: results of the family-based study. Nephrol Dial Transplant. 2001 Feb;16(2):387-90. doi: 10.1093/ndt/16.2.387.

Reference Type RESULT
PMID: 11158418 (View on PubMed)

O'Dea DF, Murphy SW, Hefferton D, Parfrey PS. Higher risk for renal failure in first-degree relatives of white patients with end-stage renal disease: a population-based study. Am J Kidney Dis. 1998 Nov;32(5):794-801. doi: 10.1016/s0272-6386(98)70135-0.

Reference Type RESULT
PMID: 9820449 (View on PubMed)

Other Identifiers

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301

Identifier Type: REGISTRY

Identifier Source: secondary_id

2016/257

Identifier Type: -

Identifier Source: org_study_id

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