The Effect of Scalp Block on Surgical Pleth Index(SPI) During a Mayfield Head-holder Insertion

NCT ID: NCT02916264

Last Updated: 2016-09-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-07-31

Study Completion Date

2017-03-31

Brief Summary

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It is a randomized control trial to compare the surgical plethysmographic index (SPI) response during a Mayfield head-holder insertion in neurosurgical patients who receive a scalp block versus those who do not receive the scalp block after induction of anesthesia with propofol with fentanyl and intubation with cis-atracurium.

Detailed Description

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Study design is a randomized controlled trial Participants include adult neurosurgical patients scheduled to have a Mayfield head-holder insertion for supratentorial craniotomy Intervention is a scalp block prior to a Mayfield head holder insertion. Comparison is 'no scalp block' Outcome is surgical plethysmographic index (SPI) responses during/after a Mayfield head holder insertion Sample size includes 30 cases (15 cases per arm)

The eligible neurosurgical patients will be randomly allocated, by a concealed randomization process, to receive or not to receive a scalp block after induction and intubation with propofol/fentanyl and cisatracurium. Surgical plethysmographic index, direct arterial blood pressure, heart rate (EEG), End tidal Carbondioxide, Bispectral/entropy (40-60) will be recorded every one minute before/after induction and intubation, before/after the scalp block, and before/after the Mayfield head-holder insertion. The Mayfield head-holder insertion will be performed by a neurosurgeon who will be blinded to the allocated groups.

Data analysis is performed to compare the change of SPI during and after the Mayfield head-holder insertion from the baseline in both groups by using repeated measure ANOVA at the significant level of 0.05.

Conditions

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Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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a scalp block

A standard scalp block ,with 0.5% bupivacaine total dose \< 3 mg/kg, is performed by an anesthesiologist.

Group Type ACTIVE_COMPARATOR

a scalp block

Intervention Type PROCEDURE

Bilateral blocks of six nerves: ie. supraorbital and supraorbital nerves (V1), zygomaticotemporal nerves (V2) , auriculotemporal nerves , greater occipital nerves, and lesser occipital nerves will be performed by a well trained anesthesiologist with 0.5% bupivacaine not exceeding 3 mg/kg

no scalp block

An anesthesiology will pretend to perform the scalp block,

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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a scalp block

Bilateral blocks of six nerves: ie. supraorbital and supraorbital nerves (V1), zygomaticotemporal nerves (V2) , auriculotemporal nerves , greater occipital nerves, and lesser occipital nerves will be performed by a well trained anesthesiologist with 0.5% bupivacaine not exceeding 3 mg/kg

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* patients will receive a Mayfield head-holder insertion for supratentorial craniotomy

Exclusion Criteria

* History of chronic hypertension, Diabetes mellitus (DM), coronary heart diseases
* Receiving beta blockers
* BMI \> 30
* Coagulopathy
* severe liver and renal diseases
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chiang Mai University

OTHER

Sponsor Role lead

Responsible Party

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Sirivimol Punjasawadwong

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sirivimol Punjasawadwong, MD

Role: PRINCIPAL_INVESTIGATOR

Dpt Anesthesiology, Faculty of Medicine, Chiang Mai University

Locations

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Dpt Anesthesiology, Faculty of Medicine, Chiang Mai University

Chiang Mai, Chiang Mai, Thailand

Site Status RECRUITING

Countries

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Thailand

Central Contacts

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Sirivimol Punjasawadwong, MD

Role: CONTACT

+6653935522

Sirvimol Punjasawadwong, MD

Role: CONTACT

+6653935522

Facility Contacts

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Yodying Punjasawadwong, MD, MMed.Sc.

Role: primary

+6653935522

Yodying Punjasawadwong, MD, MMed.Sc

Role: backup

+6653935522

Other Identifiers

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03457

Identifier Type: -

Identifier Source: org_study_id

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