Short-course Antimicrobial Therapy in Sepsis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

320 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-09-30

Study Completion Date

2021-10-31

Brief Summary

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The purpose of this study is to compare the effect of a short course antimicrobial therapy (5-days) versus a 10-days therapy on sepsis-related organ dysfunction.

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Detailed Description

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Conditions

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Infection Sepsis Severe Sepsis Septic Shock

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Caregivers

Study Groups

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Group 5-days

5-days targeted antibiotic therapy

Group Type EXPERIMENTAL

Antibiotic

Intervention Type DRUG

Targeted antimicrobial therapy

Group 10-days

10-days targeted antibiotic therapy

Group Type OTHER

Antibiotic

Intervention Type DRUG

Targeted antimicrobial therapy

Interventions

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Antibiotic

Targeted antimicrobial therapy

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients who received antibiotics for presumed infection

Exclusion Criteria

* Prolonged therapy (eg, endocarditis)
* Severe immunosuppression
* Severe infections (due to viruses, parasites, or Mycobacterium tuberculosis)
* Patients previously infected or colonized with multidrug resistant pathogens and moribund patients.

Eligible Sex

ALL

Accepts Healthy Volunteers

No