Impact of Cataract Surgery on Keratoplasty Graft Survival
NCT ID: NCT02875145
Last Updated: 2016-08-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
453 participants
OBSERVATIONAL
2014-08-31
2015-08-31
Brief Summary
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Keratoplasties and cataract surgery both result in local inflammation. This may influence the density of endothelial cells, and on average there is a loss of 10% in endothelial cells within 3 months of the cataract surgery. Yet, a sufficient density of endothelial cells is required to maintain graft transparency. It may be therefore difficult to strike a balance between loss of visual acuity due to the cataract of to the loss of graft transparency over the long term.
The investigators aim to compare graft survival in patients with clear crystalline lens with and without cataract surgery.
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Keratoplasty with cataract surgery
Patients who underwent keratoplasty who also underwent a cataract surgery during follow up.
Cataract surgery
Keratoplasty without cataract surgery
Patients who underwent keratoplasty who never underwent cataract surgery.
No interventions assigned to this group
Interventions
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Cataract surgery
Eligibility Criteria
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Inclusion Criteria
* Between january 1983 and december 2012
* Age 40 and older at the time of surgery
Exclusion Criteria
* Systemic inflammatory disease
* Previous history of uveitis
40 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire de Besancon
OTHER
Responsible Party
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Principal Investigators
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Bernard Delbosc, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Opthalmology Department, CHU Besançon
Locations
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Ophthalmology Department, CHU Besançon
Besançon, , France
Countries
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Other Identifiers
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API/2014/53
Identifier Type: -
Identifier Source: org_study_id
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