Metabo-lipidomics of the Ocular Surface for Cataract Surgery
NCT ID: NCT05802550
Last Updated: 2023-12-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
100 participants
INTERVENTIONAL
2023-09-04
2024-07-15
Brief Summary
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The identification of ocular surface biomarkers predictive of the postoperative risk of ocular surface disease carries the promise of better personalized perioperative care.
Conjunctival impression cytology represents a rapid, minimally invasive method of collecting conjunctival cells, which has proven its usefulness in the evaluation of diseases of the ocular surface. The aqueous humor is directly accessible at the beginning of the surgery.
An approach combining ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry on the cells of the ocular surface and on the aqueous humor could improve our understanding of the physiopathology of ocular surface disease following cataract surgery.
This study will aim to 1) search for prognostic biomarkers of ocular surface disease after cataract surgery using a metabo-lipidomic approach 2) improve our understanding of the pathophysiological mechanisms involved.
Detailed Description
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Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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Longitudinal cohort study in cataract patients
Longitudinal, open-label, single-center cohort study in cataract patients.
Ocular Surface Disease Index
Questionnaire on ocular surface disorders
Interferometry
Non-contact examination measuring NIBUT (non-invasive break-up time), meibography and tear meniscus measurement
Oxford score
Investigation and quantification of superficial corneal punctate keratitis using the Oxford score
Conjunctival collection
Two conjunctival prints: one for metabolomic and one for lipidomic
Aqueous humor collection
Collection of 0.1 mL of aqueous humor immediately after making the accessory corneal incision at the beginning of the cataract surgery.
Quantification of Tyndall and flare
Quantification of Tyndall and flare (from 1 to 4 crosses) in anterior chamber
Interventions
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Ocular Surface Disease Index
Questionnaire on ocular surface disorders
Interferometry
Non-contact examination measuring NIBUT (non-invasive break-up time), meibography and tear meniscus measurement
Oxford score
Investigation and quantification of superficial corneal punctate keratitis using the Oxford score
Conjunctival collection
Two conjunctival prints: one for metabolomic and one for lipidomic
Aqueous humor collection
Collection of 0.1 mL of aqueous humor immediately after making the accessory corneal incision at the beginning of the cataract surgery.
Quantification of Tyndall and flare
Quantification of Tyndall and flare (from 1 to 4 crosses) in anterior chamber
Eligibility Criteria
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Inclusion Criteria
* Age \> or = 50 years
* Patient affiliated to a social security system
* Patient agreeing to participate in the study who provided his/her free and informed written consent
Exclusion Criteria
* Other types of cataract excepted age-related or diabetic cataract
* Any eye drops or treatments that may interfere with the ocular surface
* Lens wearer
* Any general pathology with a known impact on the ocular surface (auto-immune disease, allergy)
* Proven allergy to povidone-iodine or to a component of the postoperative treatment
* Patient under legal protection (safeguard of justice, curatorship and guardianship), or in a situation of deprivation of freedom
* Patient unable to understand the nature and objectives of the study
50 Years
ALL
No
Sponsors
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University Hospital, Tours
OTHER
Responsible Party
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Locations
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KHANNA
Tours, , France
Countries
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Central Contacts
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Facility Contacts
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RAOUL KANNAV KHANNA, MD
Role: primary
Other Identifiers
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DR220231
Identifier Type: -
Identifier Source: org_study_id