Scandinavian Multicenter Study to Advance Risk Stratification in Heart Disease- Ventricular Arrhythmias

NCT ID: NCT02864771

Last Updated: 2020-06-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

504 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-08-31

Study Completion Date

2050-12-31

Brief Summary

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The purpose of this study is to identify markers of increased risk for incident ventricular arrhythmias and cardiovascular events in patients already being treated with an implantable cardioverter-defibrillator (ICD) by exploring patient history and clinical findings, biological markers, ECG markers, and echocardiographic markers.

Detailed Description

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This is a multicenter prospective cohort study to assess the prognostic value of potential biomarkers for incident ventricular arrhythmias and cardiovascular events in patients with implantable cardioverter-defibrillator (ICD). In addition to information from the baseline visit and future study visits, the investigators will also register information from the patients medical records concerning comorbidities and previous medical events.

The data will be summarized with respect to demographic and baseline characteristics and risk markers/ measurements. The final diagnosis of incident cardiovascular events will be established by an adjudication committee with two senior physicians reviewing all information available on the patients, including information on the clinical outcome of the patient. The investigators will use multivariate statistical models to assess the individual performance of biomarkers/other tests.

Conditions

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Ventricular Arrhythmias Implantable Defibrillator User Biological Markers Heart Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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1

Derivation cohort (n=474); may be analyzed separately or combined with cohort #2 to enhance statistical power

No interventions assigned to this group

2

Validation cohort (patient #475 and after); may be combined with cohort #1 to enhance statistical power

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients ≥ 18 years old
* Current treatment with an ICD
* Signed written informed consent before study commencement

Exclusion Criteria

* Participation in other interventional clinical trial or previously included in the current study
* Patients not able to provide written informed consent
* Known or suspected, non-curable cancer,
* Neurological condition with short life expectancy; e.g. amyotropic lateral sclerosis (ALS)
* Patients unwilling or unable to comply with the protocol
* History of non-compliance to medical management and patients who are considered potentially unreliable by the Investigator
* History or evidence of alcohol or drug abuse with the last 12 months that may influence the participation of the patient in the study, as assessed by the Investigator during the screening phase
* Any surgical or medical condition, which in the option of the Investigator, will impair the ability of the patient to participate in the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Helse Stavanger HF

OTHER_GOV

Sponsor Role collaborator

University of Oslo

OTHER

Sponsor Role collaborator

University Hospital, Akershus

OTHER

Sponsor Role lead

Responsible Party

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Torbjorn Omland

Professor in Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Torbjørn Omland, MD,PhD, MPH

Role: PRINCIPAL_INVESTIGATOR

Professor of Medicine

Locations

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Akershus University Hospital

Lørenskog, , Norway

Site Status

Countries

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Norway

Other Identifiers

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2015/2080

Identifier Type: -

Identifier Source: org_study_id

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