Electrophysiological Study of the Functioning of Magnocellular Visual Pathway in Regular Cannabis Users
NCT ID: NCT02864680
Last Updated: 2021-04-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
163 participants
INTERVENTIONAL
2014-02-28
2019-06-30
Brief Summary
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Secondary purposes of this study are to evaluate the impact of regular use of cannabis on the temporal sensitivity of magnocellular system (visual event-related potential), on the dynamics of cortical visual processing during face perception test (visual event-related potential) and on functioning of retinal photopic and scotopic systems (electroretinogram).
The ancillary study is a genetic analysis of a group of candidate genes that aims to identify biomarkers for changes in visual processing. This will allow to distinguish among more homogeneous and specific groups in future studies on larger cannabis user population. This ancillary study concerns all participants subject to their informed consent (facultative study).
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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Cannabis users
Electroretinography
Contrast sensitivity test during Electroencephalography
Stimuli are black and white grids, having different range of spatial frequencies, presented with different contrasts on a grey background thanks to a computer monitor, in a dark room. Participants are requested to maintain central fixation. During the test patients stay sit, head hold by chin strap. A pause can be asked by participant and done at every moment. This test lasts approximately 30 minutes.
Visual simultaneity test during Electroencephalography
Two vertical bars are showed on a monitor, on the link and right of point of central fixation. Bars appear simultaneously or with a 10 to 200 ms asynchrony. Participants must determine whether stimuli are simultaneous or asynchronous and answer pressing the link button for simultaneity or right button for asynchrony. During the test patients stay sit, head hold by chin strap. A pause can be asked by participant and done at every moment. This test lasts approximately 30 minutes.
Face perception test during Electroencephalography
Faces filtered in different spatial frequence ranges are showed randomly on a monitor, in a dark room. Participants must maintain a central fixation thank to a fixation cross. During the test patients stay sit, head hold by chin strap. A pause can be asked by participant and done at every moment. This test lasts approximately 30 minutes.
CAST (cannabis abuse screening test)
Delayed Matching to Sample (DMS) test
Spatial Working Memory (SWM) test
Rapid Visual Information Processing (RVP) test
Test for attentional performance (TAP) / Divided Attention
Collection of saliva sample
In case of specific consent of participant to ancillary study, for ancillary study
Healthy volunteers, not cannabis/tobacco users
Electroretinography
Contrast sensitivity test during Electroencephalography
Stimuli are black and white grids, having different range of spatial frequencies, presented with different contrasts on a grey background thanks to a computer monitor, in a dark room. Participants are requested to maintain central fixation. During the test patients stay sit, head hold by chin strap. A pause can be asked by participant and done at every moment. This test lasts approximately 30 minutes.
Visual simultaneity test during Electroencephalography
Two vertical bars are showed on a monitor, on the link and right of point of central fixation. Bars appear simultaneously or with a 10 to 200 ms asynchrony. Participants must determine whether stimuli are simultaneous or asynchronous and answer pressing the link button for simultaneity or right button for asynchrony. During the test patients stay sit, head hold by chin strap. A pause can be asked by participant and done at every moment. This test lasts approximately 30 minutes.
Face perception test during Electroencephalography
Faces filtered in different spatial frequence ranges are showed randomly on a monitor, in a dark room. Participants must maintain a central fixation thank to a fixation cross. During the test patients stay sit, head hold by chin strap. A pause can be asked by participant and done at every moment. This test lasts approximately 30 minutes.
Delayed Matching to Sample (DMS) test
Spatial Working Memory (SWM) test
Rapid Visual Information Processing (RVP) test
Test for attentional performance (TAP) / Divided Attention
Collection of saliva sample
In case of specific consent of participant to ancillary study, for ancillary study
Healthy volunteers, tobacco users
Electroretinography
Contrast sensitivity test during Electroencephalography
Stimuli are black and white grids, having different range of spatial frequencies, presented with different contrasts on a grey background thanks to a computer monitor, in a dark room. Participants are requested to maintain central fixation. During the test patients stay sit, head hold by chin strap. A pause can be asked by participant and done at every moment. This test lasts approximately 30 minutes.
Visual simultaneity test during Electroencephalography
Two vertical bars are showed on a monitor, on the link and right of point of central fixation. Bars appear simultaneously or with a 10 to 200 ms asynchrony. Participants must determine whether stimuli are simultaneous or asynchronous and answer pressing the link button for simultaneity or right button for asynchrony. During the test patients stay sit, head hold by chin strap. A pause can be asked by participant and done at every moment. This test lasts approximately 30 minutes.
Face perception test during Electroencephalography
Faces filtered in different spatial frequence ranges are showed randomly on a monitor, in a dark room. Participants must maintain a central fixation thank to a fixation cross. During the test patients stay sit, head hold by chin strap. A pause can be asked by participant and done at every moment. This test lasts approximately 30 minutes.
Delayed Matching to Sample (DMS) test
Spatial Working Memory (SWM) test
Rapid Visual Information Processing (RVP) test
Test for attentional performance (TAP) / Divided Attention
Collection of saliva sample
In case of specific consent of participant to ancillary study, for ancillary study
Schizophrenia patients
Electroretinography
Contrast sensitivity test during Electroencephalography
Stimuli are black and white grids, having different range of spatial frequencies, presented with different contrasts on a grey background thanks to a computer monitor, in a dark room. Participants are requested to maintain central fixation. During the test patients stay sit, head hold by chin strap. A pause can be asked by participant and done at every moment. This test lasts approximately 30 minutes.
Visual simultaneity test during Electroencephalography
Two vertical bars are showed on a monitor, on the link and right of point of central fixation. Bars appear simultaneously or with a 10 to 200 ms asynchrony. Participants must determine whether stimuli are simultaneous or asynchronous and answer pressing the link button for simultaneity or right button for asynchrony. During the test patients stay sit, head hold by chin strap. A pause can be asked by participant and done at every moment. This test lasts approximately 30 minutes.
Face perception test during Electroencephalography
Faces filtered in different spatial frequence ranges are showed randomly on a monitor, in a dark room. Participants must maintain a central fixation thank to a fixation cross. During the test patients stay sit, head hold by chin strap. A pause can be asked by participant and done at every moment. This test lasts approximately 30 minutes.
CAST (cannabis abuse screening test)
PANSS (Positive And Negative Symptoms Scale) test
Delayed Matching to Sample (DMS) test
Spatial Working Memory (SWM) test
Rapid Visual Information Processing (RVP) test
Test for attentional performance (TAP) / Divided Attention
Collection of saliva sample
In case of specific consent of participant to ancillary study, for ancillary study
Interventions
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Electroretinography
Contrast sensitivity test during Electroencephalography
Stimuli are black and white grids, having different range of spatial frequencies, presented with different contrasts on a grey background thanks to a computer monitor, in a dark room. Participants are requested to maintain central fixation. During the test patients stay sit, head hold by chin strap. A pause can be asked by participant and done at every moment. This test lasts approximately 30 minutes.
Visual simultaneity test during Electroencephalography
Two vertical bars are showed on a monitor, on the link and right of point of central fixation. Bars appear simultaneously or with a 10 to 200 ms asynchrony. Participants must determine whether stimuli are simultaneous or asynchronous and answer pressing the link button for simultaneity or right button for asynchrony. During the test patients stay sit, head hold by chin strap. A pause can be asked by participant and done at every moment. This test lasts approximately 30 minutes.
Face perception test during Electroencephalography
Faces filtered in different spatial frequence ranges are showed randomly on a monitor, in a dark room. Participants must maintain a central fixation thank to a fixation cross. During the test patients stay sit, head hold by chin strap. A pause can be asked by participant and done at every moment. This test lasts approximately 30 minutes.
CAST (cannabis abuse screening test)
PANSS (Positive And Negative Symptoms Scale) test
Delayed Matching to Sample (DMS) test
Spatial Working Memory (SWM) test
Rapid Visual Information Processing (RVP) test
Test for attentional performance (TAP) / Divided Attention
Collection of saliva sample
In case of specific consent of participant to ancillary study, for ancillary study
Eligibility Criteria
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Inclusion Criteria
* Normal visual acuity or adjusted to normal and normal dilated fundus examination
* Signature of informed consent
* Cannabis user group: More than 7 cannabis uses per week during the previous month
* Cannabis user group: Positive urinary analysis for presence of cannabis
* Healthy, non user control group: Absence of cannabis and tobacco use during last 12 months
* Healthy, non user control group: Negative urinary analysis for presence of cannabis
* Healthy, non user control group: Age and sex matching with cannabis user group
* Healthy, tobacco user control group: Tobacco use from at least 12 months
* Healthy, tobacco user control group: Low to very strong addiction to tobacco (Fagerström test)
* Healthy, tobacco user control group: Absence of cannabis use from more than 12 months
* Healthy, tobacco user control group: Negative urinary analysis for presence of cannabis
* Healthy, tobacco user control group:Age and sex matching with cannabis user group
* Schizophrenia patient control group: Schizophrenia according to DMS IV criteria (MINI test)
* Schizophrenia patient control group: Absence of cannabis use from more than one month (regardless of tobacco use)
* Schizophrenia patient control group: Negative urinary analysis for presence of cannabis
* Schizophrenia patient control group: Age and sex matching with cannabis user group
Exclusion Criteria
* Deficiency of the subject making difficult or impossible his/her participation to the study or the comprehension of the information
* Dyslexia
* Addiction to alcohol according to AUDIT scale
* Abuse or addiction to other substances according to DSM IV criteria
* Acute retinal disorder
* Chronic glaucoma
* Ophthalmic pathology affecting visual acuity
* Current ocular infection
* Persons under guardianship, curatorship or judicial protection
* Pregnant or breast-feeding women
* Persons with life-and-death emergency
* Absence of social security plan
* Results of preliminary medical examinations incompatible with the study
* Simultaneous participation to another therapeutic interventional study
18 Years
55 Years
ALL
Yes
Sponsors
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Central Hospital, Nancy, France
OTHER
Responsible Party
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Principal Investigators
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Vincent LAPREVOTE
Role: PRINCIPAL_INVESTIGATOR
Maison des Addictions - CHU de Nancy, France
Locations
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Maison des Addictions - CHU de Nancy, Hôpital St Julien
Nancy, , France
Countries
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References
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Remy I, Bernardin F, Ligier F, Krieg J, Maillard L, Schwan R, Schwitzer T, Laprevote V. Association between retinal and cortical visual electrophysiological impairments in schizophrenia. J Psychiatry Neurosci. 2023 May 19;48(3):E171-E178. doi: 10.1503/jpn.220224. Print 2023 May-Jun.
Bernardin F, Schwitzer T, Schwan R, Angioi-Duprez K, Ligier F, Bourion-Bedes S, Jansen C, Giersch A, Laprevote V. Altered central vision and amacrine cells dysfunction as marker of hypodopaminergic activity in treated patients with schizophrenia. Schizophr Res. 2022 Jan;239:134-141. doi: 10.1016/j.schres.2021.11.049. Epub 2021 Dec 7.
Remy I, Schwitzer T, Albuisson E, Schwan R, Krieg J, Bernardin F, Ligier F, Lalanne L, Maillard L, Laprevote V. Impaired P100 among regular cannabis users in response to magnocellular biased visual stimuli. Prog Neuropsychopharmacol Biol Psychiatry. 2022 Mar 8;113:110437. doi: 10.1016/j.pnpbp.2021.110437. Epub 2021 Sep 11.
Other Identifiers
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2013-A00097-38
Identifier Type: -
Identifier Source: org_study_id
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