Social and Emotional Brain Function in Cannabis Users

NCT ID: NCT02711371

Last Updated: 2017-02-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

43 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-07-31

Study Completion Date

2016-12-31

Brief Summary

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The aim of this functional magnetic resonance imaging (fMRI) study is to find out whether and how social and emotional brain function are altered in dependent cannabis users relative to healthy non-using control subjects after a 28 supervised abstinence period. Previous research in cannabis users has predominantly focused on cognitive functions. Moreover, studies have implicated that observed deficits in cannabis users may regenerate after a prolonged abstinence period. Findings might provide important information with respect to relapse vulnerability.

Detailed Description

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Conditions

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Cannabis Dependence

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Cannabis Dependence

Cannabis dependent individuals according to DSM 4 criteria, aged 18-40 years

fMRI

Intervention Type OTHER

Healthy

Healthy controls, socio-demographically matched

fMRI

Intervention Type OTHER

Interventions

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fMRI

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Cannabis dependence according to DSM 4 criteria
* 28 days of supervised abstinence

Exclusion Criteria

* other DSM 4 diagnosis
* neurological disorders
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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German Research Foundation

OTHER

Sponsor Role collaborator

University Hospital, Bonn

OTHER

Sponsor Role collaborator

University of Electronic Science and Technology of China

OTHER

Sponsor Role lead

Responsible Party

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Benjamin Becker

Prof. Dr. rer. nat.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of Bonn / Department of Psychiatry

Bonn, North Rhine-Westphalia, Germany

Site Status

Countries

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Germany

References

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Zimmermann K, Yao S, Heinz M, Zhou F, Dau W, Banger M, Weber B, Hurlemann R, Becker B. Altered orbitofrontal activity and dorsal striatal connectivity during emotion processing in dependent marijuana users after 28 days of abstinence. Psychopharmacology (Berl). 2018 Mar;235(3):849-859. doi: 10.1007/s00213-017-4803-6. Epub 2017 Dec 2.

Reference Type DERIVED
PMID: 29197984 (View on PubMed)

Other Identifiers

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ART_Can_01

Identifier Type: -

Identifier Source: org_study_id

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