Constitution of a Cohort for Monitoring Patients Candidating for Ovarian Tissue Autograft

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

240 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-05-31

Study Completion Date

2025-10-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Ovarian cryopreservation is one of the available option for preserving fertility prior to potentially sterilizing treatments. In the absence of other techniques such as in vitro folliculogenesis or injection of isolated ovarian follicles, this tissue can only be re-used by autograft. In France, the first live birth after orthotopic ovarian transplantation, was obtained by Roux et al. in 2009.

This clinical trial aims to build a cohort of patients likely to use their ovarian tissue cryopreserved by autograft.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Interest of Automated Oocyte Freezing

NCT03570073

Automatic Vitrification Manual Vitrification

UNKNOWN NA

Transplantation of Frozen Thawed Ovarian Tissue High Reproductive Performance

NCT02659592

Reproductive Performance Following Ovarian Transplantation

COMPLETED PHASE3

Preservation of Women's Fertility: Evaluation of Innovative Methods for Ovarian Tissue Cryopreservation

NCT06724471

Infertility, Female

ACTIVE_NOT_RECRUITING

FRench Elective Oocyte prEservation: a Multicenter Study thrEe Years Later

NCT07138469

Elective Fertility Preservation

COMPLETED

Risk of Infertility Related to Adjuvant Chemotherapy for Early Breast Cancer: Oocyte/Embryo Cryopreservation

NCT02871167

Breast Cancer

ACTIVE_NOT_RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Ovarian cryopreservation is one of the available option for preserving fertility prior to potentially sterilizing treatments. In the absence of other techniques such as in vitro folliculogenesis or injection of isolated ovarian follicles, this tissue can only be re-used by autograft. In France, the first live birth after orthotopic ovarian transplantation, was obtained by Roux et al. in 2009.

This clinical trial aims to build a cohort of patients likely to use their ovarian tissue cryopreserved by autograft. This cohort will be used to:

* Follow up of patients with their cryopreserved ovarian tissue;
* Evaluate requests for ovarian tissue grafting ;
* Propose a search of residual disease in case of neoplastic disease risk (if possible);
* Allowing patients to benefit from an ovarian tissue autograft;
* Assess the effectiveness of autograft technique after the restoration of ovarian function.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Ovarian Function Insufficiency

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients who have cryopreserved their ovarian tissue;
* Patients with premature ovarian insufficiency;
* Patients older than 11 years (bone age) for induction of puberty;
* Patients aged from 18 to 43 years for the restoration of ovarian function;
* No objection from the patient
* Patients who have already received ovarian tissue autograft.

Exclusion Criteria

* Patients aged under 11 years (bone age);
* Patients older than 43 years;
* Patients refusing to be included;
* Patients (adults) under guardianship, curators and safeguard justice

Minimum Eligible Age

11 Years

Maximum Eligible Age

43 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No