Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
Recruitment Status
UNKNOWN
Clinical Phase
NA
Total Enrollment
150 participants
Study Classification
INTERVENTIONAL
Study Start Date
2007-11-30
Study Completion Date
2016-08-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Endophthalmitis is a serious eye infection of exogenous origin (post-operational, post-traumatic) or endogenous origin (metastatic). This is a diagnostic and therapeutic emergency.
Each patient suffering from endophthalmitis must have immediately an ocular sampling, an intra ocular injection of antibiotics and a systemic antibiotic cover.
The etiological treatment will be adapted according to the infectious agent.
Each patient suffering from endophthalmitis must have immediately an ocular sampling, an intra ocular injection of antibiotics and a systemic antibiotic cover.
The etiological treatment will be adapted according to the infectious agent.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Severe Intraocular Infection
NCT02818062
Endophthalmitis
COMPLETED
Aqueous Humor Dynamics and Hypertensive Uveitis
NCT02765308
Uveitic Glaucoma
Anterior Uveitis
COMPLETED
Evaluation and Risk Factors of Post-traumatic Endophthalmitis
NCT06673784
Endophthalmitis
NOT_YET_RECRUITING
Comparison of Topical Anesthesia and Analgosedation in Micropulse Transscleral Glaucoma Treatment
NCT04448080
Glaucoma
COMPLETED
NA
Metabolomics in Surgical Ophthalmological Patients
NCT03098316
Primary Open-angle Glaucoma
Low Tension Glaucoma
UNKNOWN
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
The main goal of this prospective multi-centre trial is to improve the sensitivity and rapidity of the infectious agent's identification involved in endophthalmitis cases, particularly virulent species (like Staphylococcus aureus, Streptococcus pneumoniae...) from ocular samples with the help of real-time PCR.
This will help the ophthalmologist to be more efficient in accordance with the kind of the bacteria.
Data will also enable to compare both PCR techniques used in this study. The secondary goal of the prospective study is to characterize the resistance of bacterial's species found during acute endophthalmitis with the antibiogram and by the study of resistance genes, to enable to correlate the resistance in vitro with the therapeutic response in vivo and get precious epidemiological data to adapt prophylactic antibiotic.
This will help the ophthalmologist to be more efficient in accordance with the kind of the bacteria.
Data will also enable to compare both PCR techniques used in this study. The secondary goal of the prospective study is to characterize the resistance of bacterial's species found during acute endophthalmitis with the antibiogram and by the study of resistance genes, to enable to correlate the resistance in vitro with the therapeutic response in vivo and get precious epidemiological data to adapt prophylactic antibiotic.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Acute Endophthalmitis Post-operative
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
Allocation Method
NON_RANDOMIZED
Intervention Model
PARALLEL
Primary Study Purpose
DIAGNOSTIC
Blinding Strategy
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Endophthalmitis sufferers
Patients hospitalized for diagnostic and therapeutic evaluation of a post-operative acute endophthalmitis.
Group Type
OTHER
PCR : 16S ribosomal DNA and real-time targeted PCR
Intervention Type
BIOLOGICAL
Sampling of aqueous humour
Intervention Type
BIOLOGICAL
Healthy control patient
Patients hospitalized in the context of a scheduled surgery with sampling of aqueous humour.
Group Type
OTHER
PCR : 16S ribosomal DNA and real-time targeted PCR
Intervention Type
BIOLOGICAL
Sampling of aqueous humour
Intervention Type
BIOLOGICAL
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
PCR : 16S ribosomal DNA and real-time targeted PCR
Intervention Type
BIOLOGICAL
Sampling of aqueous humour
Intervention Type
BIOLOGICAL
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Subjects affiliated to the social security system
* Signed informed consent documentation
* Patients over 18 years
* Male or female person
* Patients hospitalized for diagnostic and therapeutic evaluation of a post-operative acute endophthalmitis, or within the context of a scheduled surgery with sampling of aqueous humour.
* Has given his or her consent, having been provided with detailed informations regarding to intraocular sampling.
* Signed informed consent documentation
* Patients over 18 years
* Male or female person
* Patients hospitalized for diagnostic and therapeutic evaluation of a post-operative acute endophthalmitis, or within the context of a scheduled surgery with sampling of aqueous humour.
* Has given his or her consent, having been provided with detailed informations regarding to intraocular sampling.
Exclusion Criteria
* antibiotherapy via intravenous (\< 8 days) for patients NON suffering from endophthalmitis (control group)
* Patient's participation to the study refused
* Patients under 18 years
* Patients adults under guardianship or curatorship, or unable to express his/her consent.
* Pregnant women
* Breastfeeding women
* Person deprived of liberty
* Patient's participation to the study refused
* Patients under 18 years
* Patients adults under guardianship or curatorship, or unable to express his/her consent.
* Pregnant women
* Breastfeeding women
* Person deprived of liberty
Minimum Eligible Age
18 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
University Hospital, Grenoble
OTHER
Sponsor Role
lead
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Responsibility Role
SPONSOR
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Christophe Chiquet, Doctor
Role: PRINCIPAL_INVESTIGATOR
Grenoble Hospital University
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
UniversityHospitalGrenoble
La Tronche, , France
Site Status
RECRUITING
Countries
Review the countries where the study has at least one active or historical site.
France
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
References
Explore related publications, articles, or registry entries linked to this study.
Microbiologic factors and visual outcome in the endophthalmitis vitrectomy study. Am J Ophthalmol. 1996 Dec;122(6):830-46. doi: 10.1016/s0002-9394(14)70380-0.
Reference Type
BACKGROUND
Adam D. Global antibiotic resistance in Streptococcus pneumoniae. J Antimicrob Chemother. 2002 Jul;50 Suppl:1-5. doi: 10.1093/jac/dkf801.
Reference Type
BACKGROUND
Alexandrakis G, Alfonso EC, Miller D. Shifting trends in bacterial keratitis in south Florida and emerging resistance to fluoroquinolones. Ophthalmology. 2000 Aug;107(8):1497-502. doi: 10.1016/s0161-6420(00)00179-2.
Reference Type
BACKGROUND
Anand AR, Madhavan HN, Therese KL. Use of polymerase chain reaction (PCR) and DNA probe hybridization to determine the Gram reaction of the infecting bacterium in the intraocular fluids of patients with endophthalmitis. J Infect. 2000 Nov;41(3):221-6. doi: 10.1053/jinf.2000.0731.
Reference Type
BACKGROUND
Ariyasu RG, Nakamura T, Trousdale MD, Smith RE. Intraoperative bacterial contamination of the aqueous humor. Ophthalmic Surg. 1993 Jun;24(6):367-73; discussion 373-4.
Reference Type
BACKGROUND
Auclin F, Pollet E, Roman S, Boureau-Andrieux C, Leroux-Les-Jardins S, Ullern M. [Fifty-two cases of postoperative endophthalmitis treated with one protocol: anatomical and functional results]. J Fr Ophtalmol. 2001 Sep;24(7):687-91. French.
Reference Type
BACKGROUND
Barry P, Seal DV, Gettinby G, Lees F, Peterson M, Revie CW; ESCRS Endophthalmitis Study Group. ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery: Preliminary report of principal results from a European multicenter study. J Cataract Refract Surg. 2006 Mar;32(3):407-10. doi: 10.1016/j.jcrs.2006.02.021.
Reference Type
BACKGROUND
Benz MS, Scott IU, Flynn HW Jr, Unonius N, Miller D. Endophthalmitis isolates and antibiotic sensitivities: a 6-year review of culture-proven cases. Am J Ophthalmol. 2004 Jan;137(1):38-42. doi: 10.1016/s0002-9394(03)00896-1.
Reference Type
BACKGROUND
Blondeau JM. Fluoroquinolones: mechanism of action, classification, and development of resistance. Surv Ophthalmol. 2004 Mar;49 Suppl 2:S73-8. doi: 10.1016/j.survophthal.2004.01.005.
Reference Type
BACKGROUND
Bron A. [Endophthalmitis. 1: diagnosis]. J Fr Ophtalmol. 1996;19(3):225-40. No abstract available. French.
Reference Type
BACKGROUND
Carroll NM, Jaeger EE, Choudhury S, Dunlop AA, Matheson MM, Adamson P, Okhravi N, Lightman S. Detection of and discrimination between gram-positive and gram-negative bacteria in intraocular samples by using nested PCR. J Clin Microbiol. 2000 May;38(5):1753-7. doi: 10.1128/JCM.38.5.1753-1757.2000.
Reference Type
BACKGROUND
Chen CC, Teng LJ, Chang TC. Identification of clinically relevant viridans group streptococci by sequence analysis of the 16S-23S ribosomal DNA spacer region. J Clin Microbiol. 2004 Jun;42(6):2651-7. doi: 10.1128/JCM.42.6.2651-2657.2004.
Reference Type
BACKGROUND
Chiquet C, Creuzot-Garcher C, Rouberol F, Palombi K, Bron A, Denis P, Lafontaine PO, Benito Y, Cornut PL, Thuret G, Romanet JP, Vandenesch F. Bacterial identification using PCR in a large series of acute post-cataract endophthalmitis; 2006a; Vilamoura, Portugal
Reference Type
BACKGROUND
Chiquet C, Lafontaine PO, Benito Y, Cornut PL, Palombi K, Thuret G, Creuzot-Garcher C, Denis P, Romanet JP, Vandenesch F. Bacterial identification using PCR in a large series of acute post-cataract endophthalmitis; 2006b; Fort Lauderdale, USA.
Reference Type
BACKGROUND
Chiquet C, Lina G, Benito Y, Cornut PL, Etienne J, Romanet JP, Denis P, Vandenesch F. Polymerase chain reaction identification in aqueous humor of patients with postoperative endophthalmitis. J Cataract Refract Surg. 2007 Apr;33(4):635-41. doi: 10.1016/j.jcrs.2006.12.017.
Reference Type
BACKGROUND
Corless CE, Guiver M, Borrow R, Edwards-Jones V, Fox AJ, Kaczmarski EB. Simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in suspected cases of meningitis and septicemia using real-time PCR. J Clin Microbiol. 2001 Apr;39(4):1553-8. doi: 10.1128/JCM.39.4.1553-1558.2001.
Reference Type
BACKGROUND
Cornut PL, Chiquet C, Bron A, Romanet JP, Lina G, Lafontaine PO, Benito Y, Pechinot A, Burillon C, Vandenesch F, Denis P; FRIENDS Group. Microbiologic identification of bleb-related delayed-onset endophthalmitis caused by moraxella species. J Glaucoma. 2008 Oct-Nov;17(7):541-5. doi: 10.1097/IJG.0b013e31816299ec.
Reference Type
BACKGROUND
D'Amico DJ. 2000. Principles and Practice of Ophthalmology - Postoperative endophthalmitis
Reference Type
BACKGROUND
Dickey JB, Thompson KD, Jay WM. Anterior chamber aspirate cultures after uncomplicated cataract surgery. Am J Ophthalmol. 1991 Sep 15;112(3):278-82. doi: 10.1016/s0002-9394(14)76728-5.
Reference Type
BACKGROUND
Egger SF, Huber-Spitzy V, Scholda C, Schneider B, Grabner G. Bacterial contamination during extracapsular cataract extraction. Prospective study on 200 consecutive patients. Ophthalmologica. 1994;208(2):77-81. doi: 10.1159/000310457.
Reference Type
BACKGROUND
Ferro JF, de-Pablos M, Logrono MJ, Guisasola L, Aizpuru F. Postoperative contamination after using vancomycin and gentamicin during phacoemulsification. Arch Ophthalmol. 1997 Feb;115(2):165-70. doi: 10.1001/archopht.1997.01100150167003.
Reference Type
BACKGROUND
Feys J, Emond JP, Salvanet-Bouccara A, Dublanchet A. [Bacteriological study of the intraocular fluid at the end of cataract surgery]. J Fr Ophtalmol. 1993;16(10):501-5. French.
Reference Type
BACKGROUND
Fisch A, Salvanet A, Prazuck T, Forestier F, Gerbaud L, Coscas G, Lafaix C. Epidemiology of infective endophthalmitis in France. The French Collaborative Study Group on Endophthalmitis. Lancet. 1991 Nov 30;338(8779):1373-6.
Reference Type
BACKGROUND
Gimbel HV, Sun R, DeBroff BM, Yang HM. Anterior chamber fluid cultures following phacoemulsification and posterior chamber lens implantation. Ophthalmic Surg Lasers. 1996 Feb;27(2):121-6.
Reference Type
BACKGROUND
Goldstein MH, Kowalski RP, Gordon YJ. Emerging fluoroquinolone resistance in bacterial keratitis: a 5-year review. Ophthalmology. 1999 Jul;106(7):1313-8.
Reference Type
BACKGROUND
Han DP, Wisniewski SR, Kelsey SF, Doft BH, Barza M, Pavan PR. Microbiologic yields and complication rates of vitreous needle aspiration versus mechanized vitreous biopsy in the Endophthalmitis Vitrectomy Study. Retina. 1999;19(2):98-102. doi: 10.1097/00006982-199902000-00002.
Reference Type
BACKGROUND
Han DP, Wisniewski SR, Wilson LA, Barza M, Vine AK, Doft BH, Kelsey SF. Spectrum and susceptibilities of microbiologic isolates in the Endophthalmitis Vitrectomy Study. Am J Ophthalmol. 1996 Jul;122(1):1-17. doi: 10.1016/s0002-9394(14)71959-2.
Reference Type
BACKGROUND
Hooper DC. Mechanisms of fluoroquinolone resistance. Drug Resist Updat. 1999 Feb;2(1):38-55. doi: 10.1054/drup.1998.0068.
Reference Type
BACKGROUND
Hwang DG. Fluoroquinolone resistance in ophthalmology and the potential role for newer ophthalmic fluoroquinolones. Surv Ophthalmol. 2004 Mar;49 Suppl 2:S79-83. doi: 10.1016/j.survophthal.2004.01.004.
Reference Type
BACKGROUND
Hykin PG, Tobal K, McIntyre G, Matheson MM, Towler HM, Lightman SL. The diagnosis of delayed post-operative endophthalmitis by polymerase chain reaction of bacterial DNA in vitreous samples. J Med Microbiol. 1994 Jun;40(6):408-15. doi: 10.1099/00222615-40-6-408.
Reference Type
BACKGROUND
Jaeger EE, Carroll NM, Choudhury S, Dunlop AA, Towler HM, Matheson MM, Adamson P, Okhravi N, Lightman S. Rapid detection and identification of Candida, Aspergillus, and Fusarium species in ocular samples using nested PCR. J Clin Microbiol. 2000 Aug;38(8):2902-8. doi: 10.1128/JCM.38.8.2902-2908.2000.
Reference Type
BACKGROUND
Knox CM, Cevallos V, Margolis TP, Dean D. Identification of bacterial pathogens in patients with endophthalmitis by 16S ribosomal DNA typing. Am J Ophthalmol. 1999 Oct;128(4):511-2. doi: 10.1016/s0002-9394(99)00181-6.
Reference Type
BACKGROUND
Koc F, Akcam Z, Kuruoglu S, Oge I, Gunaydin M. Does surgical technique influence cataract surgery contamination? Eur J Ophthalmol. 2001 Jan-Mar;11(1):31-6. doi: 10.1177/112067210101100107.
Reference Type
BACKGROUND
Kohn AN. Bacterial cultures of lenses removed during cataract surgery. Am J Ophthalmol. 1978 Aug;86(2):162-6. doi: 10.1016/s0002-9394(14)76805-9.
Reference Type
BACKGROUND
Koul S, Philipson A, Philipson BT. Incidence of endophthalmitis in Sweden. Acta Ophthalmol (Copenh). 1989 Oct;67(5):499-503. doi: 10.1111/j.1755-3768.1989.tb04099.x.
Reference Type
BACKGROUND
Lohmann CP, Heeb M, Linde HJ, Gabel VP, Reischl U. Diagnosis of infectious endophthalmitis after cataract surgery by polymerase chain reaction. J Cataract Refract Surg. 1998 Jun;24(6):821-6. doi: 10.1016/s0886-3350(98)80138-7.
Reference Type
BACKGROUND
Lohmann CP, Linde HJ, Reischl U. Improved detection of microorganisms by polymerase chain reaction in delayed endophthalmitis after cataract surgery. Ophthalmology. 2000 Jun;107(6):1047-51; discussion 1051-2. doi: 10.1016/s0161-6420(00)00083-x.
Reference Type
BACKGROUND
Mandelbaum S, Forster RK. 1996. Exogenous endophthalmitis. In: Pepose JS HGN, Wilhelmus K.R., editor. Ocular infection and Immunity: Mosby. p 1298-1320.
Reference Type
BACKGROUND
Mistlberger A, Ruckhofer J, Raithel E, Muller M, Alzner E, Egger SF, Grabner G. Anterior chamber contamination during cataract surgery with intraocular lens implantation. J Cataract Refract Surg. 1997 Sep;23(7):1064-9. doi: 10.1016/s0886-3350(97)80081-8.
Reference Type
BACKGROUND
Oguz H, Satici A, Guzey M, Aslan G, Tasci S. Microbiologic analysis of aqueous humor in phacoemulsification. Jpn J Ophthalmol. 1999 May-Jun;43(3):162-5. doi: 10.1016/s0021-5155(99)00013-1.
Reference Type
BACKGROUND
Okhravi N, Adamson P, Carroll N, Dunlop A, Matheson MM, Towler HM, Lightman S. PCR-based evidence of bacterial involvement in eyes with suspected intraocular infection. Invest Ophthalmol Vis Sci. 2000 Oct;41(11):3474-9.
Reference Type
BACKGROUND
Okhravi N, Adamson P, Matheson MM, Towler HM, Lightman S. PCR-RFLP-mediated detection and speciation of bacterial species causing endophthalmitis. Invest Ophthalmol Vis Sci. 2000 May;41(6):1438-47.
Reference Type
BACKGROUND
Passemard M, Lafontaine PO, Pechinot A, Cornut PL, Rouberol F, Romanet JP, Bron A, Creuzot-Garcher C, Chiquet C. Antibiotic resistances of bacteria identified in an Endophthalmitis Prospective Study.; 2006; Fort lauderdale, USA.
Reference Type
BACKGROUND
Pospisil A, Pospisil F, Dupont MJ, Delbosc B, Montard M. [Bacterial contamination of the anterior chamber and cataract surgery]. J Fr Ophtalmol. 1993;16(1):10-3. French.
Reference Type
BACKGROUND
Recchia FM, Busbee BG, Pearlman RB, Carvalho-Recchia CA, Ho AC. Changing trends in the microbiologic aspects of postcataract endophthalmitis. Arch Ophthalmol. 2005 Mar;123(3):341-6. doi: 10.1001/archopht.123.3.341.
Reference Type
BACKGROUND
Records RE, Iwen PC. Experimental bacterial endophthalmitis following extracapsular lens extraction. Exp Eye Res. 1989 Nov;49(5):729-37. doi: 10.1016/s0014-4835(89)80034-x.
Reference Type
BACKGROUND
Relman DA. 1993. Universal bacterial 16S rDNA amplification and sequencing. In: Persing DHea, editor. Diagnostic molecular microbiology Principles and applications. Washington, DC: ASM. p 489-495.
Reference Type
BACKGROUND
Sakai H, Procop GW, Kobayashi N, Togawa D, Wilson DA, Borden L, Krebs V, Bauer TW. Simultaneous detection of Staphylococcus aureus and coagulase-negative staphylococci in positive blood cultures by real-time PCR with two fluorescence resonance energy transfer probe sets. J Clin Microbiol. 2004 Dec;42(12):5739-44. doi: 10.1128/JCM.42.12.5739-5744.2004.
Reference Type
BACKGROUND
Salvanet-Bouccara A, Forestier F, Coscas G, Adenis JP, Denis F. [Bacterial endophthalmitis. Ophthalmological results of a national multicenter prospective survey]. J Fr Ophtalmol. 1992;15(12):669-78. French.
Reference Type
BACKGROUND
Samson CM, Foster CS. 2002. Masquerades syndromes: endophthalmitis. In: A.T. FCSaV, editor. Diagnosis and treatment of uveitis. Philadelphia: WB Saunders. p 528-536.
Reference Type
BACKGROUND
Seal DV, Barry P, Gettinby G, Lees F, Peterson M, Revie CW, Wilhelmus KR; ESCRS Endophthalmitis Study Group. ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery: Case for a European multicenter study. J Cataract Refract Surg. 2006 Mar;32(3):396-406. doi: 10.1016/j.jcrs.2006.02.014.
Reference Type
BACKGROUND
Sobaci G, Tuncer K, Tas A, Ozyurt M, Bayer A, Kutlu U. The effect of intraoperative antibiotics in irrigating solutions on aqueous humor contamination and endophthalmitis after phacoemulsification surgery. Eur J Ophthalmol. 2003 Nov-Dec;13(9-10):773-8. doi: 10.1177/1120672103013009-1007.
Reference Type
BACKGROUND
Speaker MG, Milch FA, Shah MK, Eisner W, Kreiswirth BN. Role of external bacterial flora in the pathogenesis of acute postoperative endophthalmitis. Ophthalmology. 1991 May;98(5):639-49; discussion 650. doi: 10.1016/s0161-6420(91)32239-5.
Reference Type
BACKGROUND
Srinivasan R, Tiroumal S, Kanungo R, Natarajan MK. Microbial contamination of the anterior chamber during phacoemulsification. J Cataract Refract Surg. 2002 Dec;28(12):2173-6. doi: 10.1016/s0886-3350(02)01493-1.
Reference Type
BACKGROUND
Stefani S, Varaldo PE. Epidemiology of methicillin-resistant staphylococci in Europe. Clin Microbiol Infect. 2003 Dec;9(12):1179-86. doi: 10.1111/j.1469-0691.2003.00698.x.
Reference Type
BACKGROUND
Tervo T, Ljungberg P, Kautiainen T, Puska P, Lehto I, Raivio I, Jarvinen E, Kuusela P, Tarkkanen A. Prospective evaluation of external ocular microbial growth and aqueous humor contamination during cataract surgery. J Cataract Refract Surg. 1999 Jan;25(1):65-71. doi: 10.1016/s0886-3350(99)80013-3.
Reference Type
BACKGROUND
Therese KL, Anand AR, Madhavan HN. Polymerase chain reaction in the diagnosis of bacterial endophthalmitis. Br J Ophthalmol. 1998 Sep;82(9):1078-82. doi: 10.1136/bjo.82.9.1078.
Reference Type
BACKGROUND
Watanabe K, Numata-Watanabe K, Hayasaka S. Methicillin-resistant staphylococci and ofloxacin-resistant bacteria from clinically healthy conjunctivas. Ophthalmic Res. 2001 May-Jun;33(3):136-9. doi: 10.1159/000055659.
Reference Type
BACKGROUND
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
38RC07.006
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.
Advanced Glaucoma Progression Study
NCT01742819
ACTIVE_NOT_RECRUITING
Study of OCT Peripapillary Angiography in Patients With Advanced Glaucoma
NCT06274593
RECRUITING
How Safe and Effective is Micropulse Transscleral Cyclophotocoagulation in Patients With Uncontrolled Glaucoma?
NCT02627352
COMPLETED
NA
Prevalence of Toxoplasma Gondii and Toxocara Canis Among Patients With Uveitis
NCT01837056
COMPLETED
Prophylactic Anecortave Acetate in Patients With a Retisert Implant
NCT00570479
COMPLETED
PHASE1
Prospective Randomized Study Comparing Ex-PRESS to Trabeculectomy
NCT01263561
COMPLETED
NA
Advanced Glycation End Products as a Biomarker for Accelerated Ageing
NCT02863224
COMPLETED
Inflammatory Mediators of Glaucoma After Corneal Transplantation (AH-Tears)
NCT04339907
UNKNOWN
NA
Retinal Vascular Reactivity in Subjects With Newly Diagnosed Glaucoma Before and After Selective Laser Trabeculoplasty
NCT01209975
UNKNOWN
PRM-151 in the Prevention of Scarring Following Trabeculectomy
NCT01064817
COMPLETED
PHASE2
Ultrastructural Changes of Trabeculectomy Specimens in Patients With Uveitic Secondary Glaucoma
NCT00917670
COMPLETED
Endoscopic Cyclophotocoagulation in Normal Tension Glaucoma
NCT04651530
RECRUITING
NA
Measurement of Ocular Tensional Fluctuation by Triggerfish Lens Before and After Cataract Surgery in Patients With Exfoliative Glaucoma
NCT02658071
UNKNOWN
Micropulse Laser Trabeculoplasty (MLT) Versus Selective Laser Trabeculoplasty (SLT) for Treatment of Open Angle Glaucoma
NCT01956942
COMPLETED
NA
Bleb Function and Morphology With Intratendon Injection of MMC Compared With Standard Method
NCT02385370
UNKNOWN
PHASE3
Micropulse Laser Trabeculoplasty (532nm) Versus Conventional Laser Trabeculoplasty (532nm)
NCT01788319
COMPLETED
NA
Effects of Selective Laser Trabeculoplasty
NCT00986141
TERMINATED
Trabeculectomy With MMC and I Stent in Uveitic Glaucoma and POAG : Outcomes and Prognostic Factors
NCT03293251
UNKNOWN
Conjunctival Vascularity Changes Usnig OCTA After Trabeculectomy
NCT04493073
UNKNOWN
EARLY_PHASE1
Primary Tube Versus Trabeculectomy Study
NCT00666237
COMPLETED
PHASE4
Prevention of Neovascular Glaucoma by Intravitreal Injections of Anti-VEGF in Patients Treated with Proton Therapy for a Large Choroidal Melanoma
NCT03172299
COMPLETED
PHASE3
mRNA Expression in Lymphocytes of Glaucoma Patients
NCT00327509
COMPLETED
Central Serous Chorioretinopathy and Micropulse Laser Treatment
NCT06346405
RECRUITING
Different Treatment Approaches of Presumed Trematode-Induced Uveitis
NCT06260449
ACTIVE_NOT_RECRUITING
NA
Foot Reflexology in Ocular Hypertensive and Glaucoma Patients
NCT04695314
COMPLETED
NA