Retinal Vascular Reactivity in Subjects With Newly Diagnosed Glaucoma Before and After Selective Laser Trabeculoplasty

NCT ID: NCT01209975

Last Updated: 2010-09-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

12 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-11-30

Brief Summary

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The purpose of this study is to assess retinal blood flow and vascular reactivity in patients with newly diagnosed primary open angle glaucoma pre- and post-primary Selective Laser Trabeculoplasty(SLT). Canon Laser Blood Flowmeter will be used for the assessment of retinal blood flow.

Detailed Description

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We previously found that vascular reactivity improved after short term treatment with dorzolamide drops. It is not clear whether this improvement was a direct effect of the medication or secondary effect of the decrease in IOP. We would like to see the change of vascular reactivity before and after SLT, which will decrease the intraocular pressure without pharmacologic effect.

Conditions

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Glaucoma

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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untreated glaucoma patients

We will evaluate the blood flow before and after Selective Laser Trabeculoplasty in patients with primary open angel glaucoma.

Selective Laser Trabeculoplasty

Intervention Type PROCEDURE

Patient will have selective laser trabeculoplasty as the first treatment for glaucoma. This treatment will be dictated clinically, since we do not assign the interventions.

Interventions

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Selective Laser Trabeculoplasty

Patient will have selective laser trabeculoplasty as the first treatment for glaucoma. This treatment will be dictated clinically, since we do not assign the interventions.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. Age 40-75 years (Male or Female)
2. Best corrected visual acuity of at least 20/40
3. No previous treatment for glaucoma
4. Ametropia less than ±6.0 DS and ±2.5 DC)
5. Non-smoker
6. No cardiovascular/respiratory disorders

Exclusion Criteria

1. Past history of diabetes and cerebrovascular accident
2. Vascular occlusive disease affecting the ocular circulation such as: diabetic retinopathy, retinal vein occlusion and retinal artery occlusion
3. Previous intraocular surgery
4. Ocular media opacities limiting the use of the imaging tests
Minimum Eligible Age

40 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Western Ontario, Canada

OTHER

Sponsor Role collaborator

University of Toronto

OTHER

Sponsor Role lead

Responsible Party

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Department of Ophthalmology and Vision Science

Principal Investigators

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Chris Hudson, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Toronto

Locations

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Toronto Western Hospital

Toronto, Ontario, Canada

Site Status RECRUITING

Countries

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Canada

Central Contacts

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Tien Wong

Role: CONTACT

416-603-5694

Facility Contacts

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Tien Wong

Role: primary

416-603-5694

References

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Venkataraman ST, Hudson C, Rachmiel R, Buys YM, Markowitz SN, Fisher JA, Trope GE, Flanagan JG. Retinal arteriolar vascular reactivity in untreated and progressive primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2010 Apr;51(4):2043-50. doi: 10.1167/iovs.09-3630. Epub 2009 Nov 11.

Reference Type BACKGROUND
PMID: 19907031 (View on PubMed)

Other Identifiers

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SLT-blood flow study

Identifier Type: -

Identifier Source: org_study_id