Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
35 participants
INTERVENTIONAL
2013-01-31
2017-09-30
Brief Summary
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Detailed Description
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Commercial aircrafts have their altitude compensation adjusted to 2500 meter above sea level which corresponds to a pressure difference of about 270 hPa. This causes a reduction of the partial pressure of oxygen during the flight. Patients with lung disease are especially challenged by large walking distances within airports and during their journey. The objective of our study is to evaluate the impact of a simulated flight under hyperbaric conditions on walking endurance in healthy individuals as well as in COPD Patients with and without hypercapnia.
Method:
Healthy individuals as well as COPD patients were assessed pre-flight with the following measurements:
1. Arterial blood gas analysis
2. Lung function test
3. Lung diffusion test
4. Hemoglobin level
5. Six minute walking distance
During the flight measurements included (measured every 30 minutes until landing):
1. Heartrate
2. Oxygen saturation
3. Borg scale
Post flight measurements included:
1. Arterial blood gas analysis
2. Six minute walking distance
Intended analysis:
* Description of endurance response as a function of COPD disease severity.
* Description of endurance response in normocapnic and hypercapnic COPD patients.
* Detection of pre-flight predictors that determine flight tolerability and hypoxic response.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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healthy subjects
three hour flight simulation
Environmental
hypobaric flight simulation
COPD normocapnic
three hour flight simulation
Environmental
hypobaric flight simulation
COPD hypercapnic
three hour flight simulation
Environmental
hypobaric flight simulation
Interventions
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Environmental
hypobaric flight simulation
Eligibility Criteria
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Inclusion Criteria
* COPD without hypercapnea
* COPD with hypercapnea
Exclusion Criteria
* Renal insufficiency
* Heart failure (ejection fraction \< 45 %)
18 Years
ALL
Yes
Sponsors
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Krankenhaus Kloster Grafschaft
OTHER
Responsible Party
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Dominic Dellweg, M.D.
PD Dr. med
Locations
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Kloster Grafschaft
Schmallenberg, North Rhine-Westphalia, Germany
Countries
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Other Identifiers
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Airtravel01
Identifier Type: -
Identifier Source: org_study_id
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