STREAMER : STent Restenosis And MEdicaments Release

NCT ID: NCT02835586

Last Updated: 2016-07-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-05-31

Study Completion Date

2015-11-30

Brief Summary

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It is a pilot study to evaluate the feasibility and the efficiency of local delivery of paclitaxel after stenting of long femoropopliteal arterial lesions TASC C and D before the realization of a large randomized multicentric study. Patients concerned are in critical ischemia.

Detailed Description

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Conditions

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Critical Ischemia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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paclitaxel delivery in femoropopliteal artery

Group Type EXPERIMENTAL

Paclitaxel

Intervention Type DRUG

Paclitaxel will be administered intra-arterially through an irrigating catheter to treat a diseased segment of superficial femoral artery and/or popliteal artery after stenting. Dosing will be based on the lesion surface area and will be calculated using the following formula : 22/7 x diameter (mm) x length (mm) x 3 µg/mm3

Interventions

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Paclitaxel

Paclitaxel will be administered intra-arterially through an irrigating catheter to treat a diseased segment of superficial femoral artery and/or popliteal artery after stenting. Dosing will be based on the lesion surface area and will be calculated using the following formula : 22/7 x diameter (mm) x length (mm) x 3 µg/mm3

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* patients with critical ischemia of a lower limb with ankle pressure \< 50 mmHg
* lesions TASC C and D of the superficial femoral or popliteal artery

Exclusion Criteria

* patient allergic to paclitaxel
* patient with a cancer, a neutropenia, with immunosuppressor medicament or chemotherapy
* patient with contraindication to take 2 anti-aggregants platelets
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Nellie DELLA SCHIAVA, MD

Role: PRINCIPAL_INVESTIGATOR

department of vascular surgery, Edouard Herriot Hospital, LYON

Locations

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department of vascular surgery, Edouard Herriot Hospital, 5 Place d'Arsonval

Lyon, , France

Site Status

Countries

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France

Other Identifiers

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2011-701

Identifier Type: -

Identifier Source: org_study_id

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