MedDataX Logo

Predicting Success of HFNC: The Utility of the ROX Index

NCT ID: NCT02834325

Last Updated: 2016-07-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

201 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-01-31

Study Completion Date

2012-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of the study was to describe early predictors and to develop a prediction tool that accurately identifies the need for mechanical ventilation in pneumonia patients with acute respiratory failure treated with High Flow nasal cannula.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

ROX Index Versus MROX Index to Predict Treatment Outcome for High Flow Nasal Cannula And/or Noninvasive Ventilation in Patients with Respiratory Failure

NCT06715644

Respiratory Failure
NOT_YET_RECRUITING

Predictors of Failure of Non-invasive Ventilation and High Flow Nasal Cannula

NCT05864898

Acute Respiratory Failure Patients on NIV and HFNC
UNKNOWN

ROX Index for the Timing of Intubation in Nasal High Flow

NCT04707729

Acute Hypoxemic Respiratory Failure
RECRUITING NA

A Novel Index to Predict the Failure of High-flow Nasal Cannula in Patients with Acute Hypoxemic Respiratory Failure

NCT05549882

Acute Hypoxemic Respiratory Failure
COMPLETED

PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study

NCT06716463

Ventilatory Failure Hypoxemic Respiratory Failure Weaning Failure +1 more
RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Purpose The purpose of the study is to describe early predictors and to develop a prediction tool that accurately identifies the need for mechanical ventilation (MV) in pneumonia patients with hypoxemic acute respiratory failure (ARF) treated with high-flow nasal cannula (HFNC).

Materials and methods This is a 4-year prospective observational 2-center cohort study including patients with severe pneumonia treated with HFNC. High-flow nasal cannula failure was defined as need for MV. ROX index was defined as the ratio of pulse oximetry/fraction of inspired oxygen to respiratory rate.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Acute Respiratory Failure Pneumonia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

exit

HFNC with no need for mechanical ventilation

No interventions assigned to this group

failure

HFNC with need for mechanical ventilation

mechanical ventilation

Intervention Type PROCEDURE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

mechanical ventilation

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* diagnosis of acute respiratory failure secondary to pneumonia receiving HFNC therapy

Exclusion Criteria

* younger than 18 years old
* indication for mechanical ventilation at ICU admission
* limitation of therapeutic effort
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Hospital Universitari Vall d'Hebron Research Institute

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

PR(AG)101/2011

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Use of High Flow Nasal Cannula Oxygen and Covid-19 Acute Hypoxemic Respiratory Failure
NCT04385823 COMPLETED
Assessment Of Different Indices in Prediction of Noninvasive Ventilation Failure in Patients With Acute Respiratory Failure
NCT05850195 UNKNOWN
Comparison of Pre-oxygenation of NIV and HFNC Therapy for Intubation of ICU Patients With Acute Respiratory Failure
NCT02668458 COMPLETED NA
Non-invasive Ventilation Versus High Flow Oxygen
NCT03758508 RECRUITING NA
Fluid Responsiveness in HFNC Patients
NCT03817996 COMPLETED
The Effectiveness of High-flow Nasal Cannula After Extubation in Patients
NCT06746363 COMPLETED
High-flow Oxygen Therapy vs Non-invasive Ventilation: Comparison of Alveolar Recruitment in Acute Respiratory Failure
NCT04664322 COMPLETED
Efficacy and Safety of High-Flow Nasal Cannula Versus Noninvasive Ventilation for Pulmonary Arterial Hypertension-Associated Acute Respiratory Failure
NCT06582459 ACTIVE_NOT_RECRUITING
Physiological Effects of a New Interface on Lung Ventilation and Gas Distribution
NCT04619641 UNKNOWN NA
HFNC During Bronchoscopy for Bronchoalveolar Lavage
NCT04016480 COMPLETED NA
Weaning From Nasal High Flow Therapy
NCT05210881 COMPLETED
HFNC and Prone Positioning in Awake Patients With Severe COVID-19
NCT04982341 COMPLETED
Study of High Flow Nasal Cannula Oxygen for Bronchoscopy With Bronchoalveolar Lavage in ICU Patients
NCT02523573 COMPLETED
High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease
NCT03033251 RECRUITING NA
HFNC and Acute Hypercapnic Respiratory Failure
NCT04109560 COMPLETED
Standard Oxygen Versus High Flow Nasal Cannula Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure
NCT04468126 COMPLETED NA
High-flow Nasal Cannula Oxygen Therapy With or Without NIV During the Weaning Period
NCT03121482 COMPLETED NA
Correlation of Peak Tidal Inspiratory Flow Measured Before and After Extubation in Adult Patients With Hypoxemia
NCT04971148 TERMINATED NA
Awake Prone Positioning of Patients Suffering Community Acquired Pneumonia Requiring Nasal High Flow Therapy
NCT06966310 NOT_YET_RECRUITING NA
The Effect of Non-invasive Respiratory Support on Outcome and Its Risks in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2)-Related Hypoxemic Respiratory Failure
NCT06033560 UNKNOWN
The Effects of Flow Settings During High Flow Nasal Cannula for Adult Hypoxemia Patients
NCT03738345 COMPLETED NA
Identifying the Best Flow Setting Strategy for High-Flow Nasal Cannula
NCT07007715 RECRUITING NA
High Flow Oxygen Therapy in Patients Suffering From Chronic Obstructive Pulmonary Disease Exacerbation: Effects and Mechanisms of Action
NCT02371564 UNKNOWN NA
High Flow Nasal Cannula With Noninvasive Ventilation
NCT04507425 COMPLETED NA
High Flow Nasal Canula Oxygen Helps Preoxygenate ARDS Patients
NCT02214576 COMPLETED