Exercise and Ectopic Fat Deposition

NCT ID: NCT02831621

Last Updated: 2019-01-25

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-06-30
• Study Completion Date: 2019-01-31

Brief Summary

Excess ectopic fat deposition is associated with development of cardiovascular and metabolic diseases. This study investigates how lifestyle interventions can have an effect on different sites of ectopic fat deposition and cardiovascular or metabolic factors. Moreover, the clinical and economic value of exercise to supplement a hypocaloric diet is investigated.

Endocrinologists of the University Hospital of Antwerp, Belgium, will be recruiting women during consultations. Also, recruitment posters will be used in the University Hospital of Antwerp and the University of Antwerp. Potential participants meeting all a priori set inclusion and exclusion criteria will be randomized by minimization method to a hypocaloric diet group (usual care) or a group of hypocaloric diet combined with physical fitness training. Both groups will undergo an intake procedure in which personal goals are set and barriers to changes in behavior will be discussed. Ectopic fat deposition will be measured by imaging techniques after three and six months of intervention. Based on the known relationship between ectopic fat and cardiovascular outcomes, the short term study results will then be extrapolated to an estimation of the reduction of cardiovascular events.

The following clinical outcomes will be presented: change in ectopic fat in the abdomen (visceral fat), the liver (intra hepatic lipids), skeletal muscle (intra myocellular lipids), heart (epicardial fat) after a dietary or combined (diet+physical activity) intervention. The impact of supervised exercise in addition to diet will be expressed in projected healthcare costs and quality adjusted life years.

Detailed Description

protocol of the study was published, Hens et al. (physioscience 2017; 13: 80-87)

Conditions

Overweight

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

diet (usual care)

All participants will receive a hypocaloric diet based on the individual resting metabolic rate. Resting metabolic rate (RMR) will be estimated using the WHO formula or measured using indirect calorimetry. Total energy expenditure will be calculated by multiplying RMR with a physical activity level (PAL). The used physical activity level will be 1.3. A hypocaloric diet with an energy deficit of 500 kcal/day will be prescribed. Participants will see a skilled dietician two-weekly the first month and on a monthly basis the next five months to discuss problems and solutions or coping strategies. The first consultation will have a duration of 60 minutes, the next consultations will have a duration of approximately 30 minutes. Each visit, nutritional compliance will be recorded on a 0 to 10 numeric rating scale. The usual care group will be asked to continue with their normal physical activity during the six-month intervention period.

Group Type: ACTIVE_COMPARATOR

lifestyle intervention (diet OR diet+exercise)

Intervention Type: BEHAVIORAL

diet or diet+fitness training

diet+exercise

For participants of this group, usual care will be supplemented with a prescribed exercise program. For this exercise program the participants will be referred to a local fitness club near home, free of charge. Aerobic training will be done at an intensity of 90-95% of the heart rate achieved at the RCP. Aerobic training will have a duration of 30 to 45 minutes, according to the training stage. Cardio training will be performed on different cardio devices and strength training will be done on isotonic strength training devices. Each training day, core stability training will be completed with four strength exercises for large muscle groups. Each exercise will be done in two sets of 15 repetitions with the goal to achieve better muscular strength endurance.

This combined training will be done individually during six months, three times/week.

In this study, an effort is made to reach a uniform manner of guidance to the physical activity program.

Group Type: EXPERIMENTAL

lifestyle intervention (diet OR diet+exercise)

Intervention Type: BEHAVIORAL

diet or diet+fitness training

Interventions

lifestyle intervention (diet OR diet+exercise)

diet or diet+fitness training

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Participants should be willing to undergo a weight loss intervention and body weight must be stable during the past six months.
• There will be no upper eligibility criterion for body mass index (BMI) but BMI should be at least 27 kg/m².

Exclusion Criteria

• Individuals who have a clinical history of type 2 diabetes, prediabetes (with use of medication), or hypothyroidism will be excluded.
• when postmenopausal; Premenopausal state will be verified by hormonal data (follicle-stimulation hormone (FSH) < 25 mU/ml and estradiol > 20 pg/ml).
• Subjects will not be allowed when pregnancy is planned
• when physical activity is not possible due to problems of the musculoskeletal system
• when changes in medication (e.g. beta blockers) are advised by an endocrinologist.
• when smoking
• when drinking more than two alcoholic consumptions/day or binge drinking (self-reported)
• when taking medication that influences body weight or metabolism (e.g. tricyclic antidepressants)

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Universiteit Antwerpen

OTHER

Sponsor Role: lead

Responsible Party

Wendy Hens

candidate PHD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

University Hospital of Antwerp

Antwerp, , Belgium

Countries

Belgium

References

Hens W, Vissers D, Annemans L, Gielen J, Van Gaal L, Taeymans J, Verhaeghe N. Health-related costs in a sample of premenopausal non-diabetic overweight or obese females in Antwerp region: a cost-of-illness analysis. Arch Public Health. 2018 Jul 30;76:42. doi: 10.1186/s13690-018-0285-1. eCollection 2018.

Reference Type: DERIVED

PMID: 30069308 (View on PubMed)

Other Identifiers

14/17/205

Identifier Type: -

Identifier Source: org_study_id